2-[2-(Methylthio)phenoxy]ethylamine

Base Information

• Chemical Name: 2-[2-(Methylthio)phenoxy]ethylamine
• CAS No.: 72955-86-3
• Molecular Formula: C9H13NOS
• Molecular Weight: 183.27100
• Hs Code.: 2930909090
• Mol file: 72955-86-3.mol

Synonyms:2-(2-Methylmercaptophenoxy)-aethylamin;2-(2-(Methylthio)phenoxy)ethanamine;2-(2-methylthiophenoxy)-ethylamine;

Chemical Property of 2-[2-(Methylthio)phenoxy]ethylamine

Chemical Property:

• Boiling Point: 303.1±27.0 °C(Predicted)
• PKA: 8.36±0.10(Predicted)
• PSA: 60.55000
• Density: 1.12±0.1 g/cm3(Predicted)
• LogP: 2.44630
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-[2-(Methylthio)phenoxy]ethylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[2-(Methylthio)phenoxy]ethylamine

There total 6 articles about 2-[2-(Methylthio)phenoxy]ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

N-[2-(2-methylthiophenoxy)ethyl]phthalimide (850895-62-4) → 2-(2-methylthiophenoxy)ethylamine (72955-86-3)

Guidance literature:

With hydrogenchloride; hydrazine hydrate; In 2-methoxy-ethanol; at 125 ℃; for 2h;

DOI:10.1016/j.bmc.2005.01.034

Reference yield:

2-(2-methylthiophenoxy)ethanol (37794-24-4) → 2-(2-methylthiophenoxy)ethylamine (72955-86-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 64 percent / pyridine / 0 - 20 °C

2: sodium hydride / dimethylformamide / 4 h / Heating

3: 42 percent / hydrazine hydrate; HCl / 2-methoxy-ethanol / 2 h / 125 °C

With pyridine; hydrogenchloride; sodium hydride; hydrazine hydrate; In 2-methoxy-ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2005.01.034

Reference yield:

2-(2-methylthiophenoxy)-1-tosyloxyethane (152738-51-7) → 2-(2-methylthiophenoxy)ethylamine (72955-86-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / dimethylformamide / 4 h / Heating

2: 42 percent / hydrazine hydrate; HCl / 2-methoxy-ethanol / 2 h / 125 °C

With hydrogenchloride; sodium hydride; hydrazine hydrate; In 2-methoxy-ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2005.01.034

upstream raw materials:

N-[2-(2-methylthiophenoxy)ethyl]phthalimide

2-(2-methylthiophenoxy)ethanol

2-(2-methylthiophenoxy)-1-tosyloxyethane

2-(methylsulfenyl)phenol

Downstream raw materials:

1-(9H-carbazol-4-yloxy)-3-{[2-(2-methylthiophenoxy)ethyl]-amino}-2-propanol

Refernces

• 1、 -. "CARBAZOLYL-(4)-OXYPROPANOLAMINE COMPOUNDS AND THERAPEUTIC COMPOSITIONS". . . Retrieved 2008/06/13.