Pyrrolo[3,4-b]pyrrole-1,4(4H)-dicarboxylic acid, 5,6-dihydro-2-methyl-5-(9-phenyl-9H-fluoren-9-yl)-, 1-(1,1-dimethylethyl) 4-(phenylmethyl) ester, (4S)-

Base Information

Chemical Name:Pyrrolo[3,4-b]pyrrole-1,4(4H)-dicarboxylic acid, 5,6-dihydro-2-methyl-5-(9-phenyl-9H-fluoren-9-yl)-, 1-(1,1-dimethylethyl) 4-(phenylmethyl) ester, (4S)-
CAS No.:731859-46-4
Molecular Formula:C39H36N2O4
Molecular Weight:596.726
Hs Code.:

Pyrrolo[3,4-b]pyrrole-1,4(4H)-dicarboxylic acid,
5,6-dihydro-2-methyl-5-(9-phenyl-9H-fluoren-9-yl)-, 1-(1,1-dimethylethyl)
4-(phenylmethyl) ester, (4S)-

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Suppliers and Price of Pyrrolo[3,4-b]pyrrole-1,4(4H)-dicarboxylic acid, 5,6-dihydro-2-methyl-5-(9-phenyl-9H-fluoren-9-yl)-, 1-(1,1-dimethylethyl) 4-(phenylmethyl) ester, (4S)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Pyrrolo[3,4-b]pyrrole-1,4(4H)-dicarboxylic acid, 5,6-dihydro-2-methyl-5-(9-phenyl-9H-fluoren-9-yl)-, 1-(1,1-dimethylethyl) 4-(phenylmethyl) ester, (4S)-

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Technology Process of Pyrrolo[3,4-b]pyrrole-1,4(4H)-dicarboxylic acid, 5,6-dihydro-2-methyl-5-(9-phenyl-9H-fluoren-9-yl)-, 1-(1,1-dimethylethyl) 4-(phenylmethyl) ester, (4S)-

There total 4 articles about Pyrrolo[3,4-b]pyrrole-1,4(4H)-dicarboxylic acid, 5,6-dihydro-2-methyl-5-(9-phenyl-9H-fluoren-9-yl)-, 1-(1,1-dimethylethyl) 4-(phenylmethyl) ester, (4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 79069-50-4
Boc-Ala-H

: 163594-14-7
(2S)-4-oxo-N-(9-phenylfluoren-9-yl)proline benzyl ester

: 731859-46-4
2-methyl-5-(9-phenyl-9H-fluoren-9-yl)-5,6-dihydro-4H-pyrrolo[3,4-b]pyrrole-1,4-dicarboxylic acid 4-benzyl ester 1-tert-butyl ester

Guidance literature:: (2S)-4-oxo-N-(9-phenylfluoren-9-yl)proline benzyl ester; With n-butyllithium; In tetrahydrofuran; at -78 ℃;

Boc-Ala-H; In tetrahydrofuran; at -78 ℃;

With hydrogenchloride; In dichloromethane;
DOI:10.1021/ja0471222

Reference yield:

: 3-(2-tert-butoxycarbonylamino-1-hydroxy-propyl)-4-oxo-1-(9-phenyl-9H-fluoren-9-yl)-pyrrolidine-2-carboxylic acid benzyl ester

: 731859-46-4
2-methyl-5-(9-phenyl-9H-fluoren-9-yl)-5,6-dihydro-4H-pyrrolo[3,4-b]pyrrole-1,4-dicarboxylic acid 4-benzyl ester 1-tert-butyl ester

Guidance literature:: With hydrogenchloride; In dichloromethane;
DOI:10.1021/jo049612i

Reference yield:

: 105499-11-4
2-(Boc-amino)propionaldehyde

: 731859-46-4
2-methyl-5-(9-phenyl-9H-fluoren-9-yl)-5,6-dihydro-4H-pyrrolo[3,4-b]pyrrole-1,4-dicarboxylic acid 4-benzyl ester 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -55 °C

1.2: tetrahydrofuran; hexane / -55 °C

2.1: HCl / CH₂Cl₂

With hydrogenchloride; n-butyllithium; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo049612i