2-Mercapto-2,2-diMethylethanol

Base Information

• Chemical Name: 2-Mercapto-2,2-diMethylethanol
• CAS No.: 73303-88-5
• Molecular Formula: C4H10OS
• Molecular Weight: 106.189
• Mol file: 73303-88-5.mol

Synonyms:2-methyl-1-hydroxypropane-2-thiol;2-Methyl-2-mercaptopropan-1-ol;2-mercapto-2-methyl-1-propanol;2-mercapto-2-methylpropan-1-ol;1-Propanol,2-mercapto-2-methyl;

Chemical Property of 2-Mercapto-2,2-diMethylethanol

Chemical Property:

• PSA: 59.03000
• LogP: 0.68710
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform, Methanol

Purity/Quality:

99% ^*data from raw suppliers

2-Mercapto-2,2-dimethylethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Mercapto-2,2-dimethylethanol is a useful synthetic intermediate and a derivative of 2-Mercaptoethanol (M225480); a compound used in the synthesis of nano-graphene for cellular imaging and drug delivery. 2-Mercaptoethanol is also used in the synthesis of multifunctional polymeric micelles used in specific targeting of tumor disruption.

Technology Process of 2-Mercapto-2,2-diMethylethanol

There total 6 articles about 2-Mercapto-2,2-diMethylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2,2'-dithiobis(2-methylpropanal) (15581-80-3) → 2-methyl-1-hydroxypropane-2-thiol (73303-88-5)

Guidance literature:

2,2'-dithiobis(2-methylpropanal); With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

With water; sodium sulfate; In tetrahydrofuran; at 20 ℃; for 0.166667h;

Reference yield: 40.0%

2,2'-dithiobis(2-mercapto-2-methylpropan-1-ol) (132182-01-5) → 2-methyl-1-hydroxypropane-2-thiol (73303-88-5)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 1h;

DOI:10.1021/ja00154a001

Reference yield:

2-acetylsulfanyl-2-methylpropionic acid ethyl ester (1151713-51-7) → 2-methyl-1-hydroxypropane-2-thiol (73303-88-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 80 ℃; for 2h;

upstream raw materials:

1-acetoxy-2-acetylsulfanyl-2-methyl-propane

trimethylsilyl 2-(methoxycarbonyl)-2-propanesulfinate

2,2'-dithiobis(2-mercapto-2-methylpropan-1-ol)

2,2'-dithiobis(2-methylpropanal)

Downstream raw materials:

4,4-Dimethyl-1,3-dioxathiolane

6,6-Dimethyl-1,3-dioxa-5-thiacycloheptane

2-methyl-1-hydroxypropane-2-nitrosothiol

Refernces

• 1、 -. "CONJUGATED CHEMICAL INDUCERS OF DEGRADATION AND METHODS OF USE". Page/Page column 411-412. . Retrieved 2020/05/28.
• 2、 -. "AMINO-QUINOLINES AS KINASE INHIBITORS". Paragraph 0184. . Retrieved 2015/09/23.