sodium (6R-trans)-3-(acetoxymethyl)-8-oxo-7-(1H-tetrazol-1-ylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Base Information

Chemical Name:sodium (6R-trans)-3-(acetoxymethyl)-8-oxo-7-(1H-tetrazol-1-ylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
CAS No.:27164-45-0
Molecular Formula:C13H14 N6 O6 S . Na
Molecular Weight:404.339
Hs Code.:
Mol file:27164-45-0.mol

Synonyms:5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 3-(hydroxymethyl)-8-oxo-7-[2-(1H-tetrazol-1-yl)acetamido]-, acetate(ester), monosodium salt (8CI);5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,3-[(acetyloxy)methyl]-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-, monosodiumsalt, (6R-trans)- (9CI); Sodium 7-(1H-tetrazol-1-acetamido)cephalosporanate

Suppliers and Price of sodium (6R-trans)-3-(acetoxymethyl)-8-oxo-7-(1H-tetrazol-1-ylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Sodium7-(1H-Tetrazol-1-acetamido)cephalosporanate
100mg
$ 1980.00

Total 8 raw suppliers

Chemical Property of sodium (6R-trans)-3-(acetoxymethyl)-8-oxo-7-(1H-tetrazol-1-ylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：184.74000
Density:g/cm³
LogP:-3.03110

Purity/Quality:

99% ^*data from raw suppliers

Sodium7-(1H-Tetrazol-1-acetamido)cephalosporanate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Sodium 7-(1H-Tetrazol-1-acetamido)cephalosporanate is an impurity of the antibiotic Cefazolin (C242500).

Technology Process of sodium (6R-trans)-3-(acetoxymethyl)-8-oxo-7-(1H-tetrazol-1-ylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

There total 2 articles about sodium (6R-trans)-3-(acetoxymethyl)-8-oxo-7-(1H-tetrazol-1-ylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 957-68-6
7-Aminocephalosporanic acid

: 27164-45-0
(6R)-3-acetoxymethyl-7t-(2-tetrazol-1-yl-acetylamino)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid; sodium salt

Guidance literature:: Multi-step reaction with 2 steps

1: 1,5-diazabicyclo<4.3.0>non-5-ene (DBN) / CH₂Cl₂ / Heating

2: 1.) triethylamine, 2.) sodium ethyl acetoacetate / 1.CH₂Cl₂, pH=4.5, 60 min, 2.) isopropanol, pH=6.8

With sodium ethyl acetoacetate; DBN; triethylamine; In dichloromethane;
DOI:10.1016/S0040-4020(01)96757-2

Reference yield:

: Dimethyl-(2-tetrazol-1-yl-acetoxysulfinyloxymethylene)-ammonium

: 31461-04-8
(6R,7R)-Trimethylsilyl 7-(Trimethylsilyl)amino-3-acetoxy methylceph-3-em-4-carboxylate

: 27164-45-0
(6R)-3-acetoxymethyl-7t-(2-tetrazol-1-yl-acetylamino)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid; sodium salt

Guidance literature:: With sodium ethyl acetoacetate; triethylamine; Yield given. Multistep reaction; 1.CH₂Cl₂, pH=4.5, 60 min, 2.) isopropanol, pH=6.8;
DOI:10.1016/S0040-4020(01)96757-2