2-Pyrrolidinylphosphonic Acid

Base Information

Chemical Name:2-Pyrrolidinylphosphonic Acid
CAS No.:73858-59-0
Molecular Formula:C₄H₁₀NO₃P
Molecular Weight:151.102
Hs Code.:
Mol file:73858-59-0.mol

Synonyms:Pyrrolidin-2-phosphonsaeure;2-Pyrrolidinylphosphonic Acid;2-phosphonopyrrolidine;pyrrolidine-2-phosphonic acid;pyrrolidin-2-yl-phosphonic acid;

Suppliers and Price of 2-Pyrrolidinylphosphonic Acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 8 raw suppliers

Chemical Property of 2-Pyrrolidinylphosphonic Acid

Chemical Property:

Melting Point:275 °C (decomp)
Boiling Point:359.3±52.0 °C(Predicted)
PKA:0.95±0.20(Predicted)
PSA：79.37000
Density:1.42±0.1 g/cm3(Predicted)
LogP:0.20240
Storage Temp.:Refrigerator
Solubility.:DMSO (Sparingly, Heated, Sonicated), Water (Slightly)

Purity/Quality:: ≥95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 2-Pyrrolidinylphosphonic Acid, is an impurity of Alendronate (A521250), a bisphosphonate used as a bone reabsoption inhibitor.

Technology Process of 2-Pyrrolidinylphosphonic Acid

There total 9 articles about 2-Pyrrolidinylphosphonic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 347386-53-2
tert-butyl 2-(dimethoxyphosphoryl)pyrrolidine-1-carboxylate

: 73858-59-0
pyrrolidine-2-ylphosphonic acid

Guidance literature:: With hydrogenchloride; for 12h; Heating;
DOI:10.1248/cpb.49.531

Reference yield: 34.0%

: γ-chloro-α-aminobutanephosphonic acid

: 73858-59-0
pyrrolidine-2-ylphosphonic acid

Guidance literature:: With sodium hydroxide; In water; for 1h; Ambient temperature;

Reference yield:

: C₁₀H₂₂NO₃P*C₈H₁₈AlBr

: 73858-59-0
pyrrolidine-2-ylphosphonic acid

Guidance literature:: C₁₀H₂₂NO₃P*C₈H₁₈AlBr; With hydrogenchloride; In water; toluene; for 4h; Reflux; Inert atmosphere;

In water; Inert atmosphere;
DOI:10.1080/10426507.2017.1284844