Technology Process of Spiro[3.5]nonan-6-one
There total 2 articles about Spiro[3.5]nonan-6-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: toluene-4-sulfonic acid / toluene / Reflux
2: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 4 h / 45 °C
3: hydrogen; palladium 10% on activated carbon / methanol / 5.5 h / 760.05 Torr
With
palladium 10% on activated carbon; hydrogen; toluene-4-sulfonic acid; sodium bis(2-methoxyethoxy)aluminium dihydride;
In
methanol; toluene;
- Guidance literature:
-
With
hydroxocobalamine hydrochloride; lithium perchlorate; ammonium bromide;
In
N,N-dimethyl-formamide;
at 20 ℃;
electrolysis;
DOI:10.1021/ja00530a064
- Guidance literature:
-
Multi-step reaction with 7 steps
1: sodium hydride / tetrahydrofuran / 2 h / Reflux
2: potassium carbonate / tetrahydrofuran / 20 °C
3: cesium fluoride; tetrakis(triphenylphosphine) palladium(0) / methanol; 1,2-dimethoxyethane / 2 h / 70 °C / Inert atmosphere
4: lithium borohydride / tetrahydrofuran / 20 °C
5: trimethylamine; methanesulfonyl chloride / dichloromethane / 5 h / 20 °C
6: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 20 °C
7: potassium hydroxide / 1,4-dioxane / 60 °C
With
lithium borohydride; tetrakis(triphenylphosphine) palladium(0); sodium hydride; potassium carbonate; methanesulfonyl chloride; cesium fluoride; potassium iodide; potassium hydroxide; trimethylamine;
In
tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;
