L-Phenylalaninamide, N-[(2-oxo-1-imidazolidinyl)carbonyl]-L-histidyl-, monoacetate

Base Information

Chemical Name:L-Phenylalaninamide, N-[(2-oxo-1-imidazolidinyl)carbonyl]-L-histidyl-, monoacetate
CAS No.:74084-34-7
Molecular Formula:C₂H₄O₂*C₁₉H₂₃N₇O₄
Molecular Weight:473.489
Hs Code.:

Synonyms:

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Chemical Property of L-Phenylalaninamide, N-[(2-oxo-1-imidazolidinyl)carbonyl]-L-histidyl-, monoacetate

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Technology Process of L-Phenylalaninamide, N-[(2-oxo-1-imidazolidinyl)carbonyl]-L-histidyl-, monoacetate

There total 6 articles about L-Phenylalaninamide, N-[(2-oxo-1-imidazolidinyl)carbonyl]-L-histidyl-, monoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5241-56-5,17324-88-8,53562-23-5,4801-80-3
benzyl [(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]carbamate

: 74084-34-7
2-oxoimidazolidine-1-carbonyl-histidyl-phenylalanine amide acetate

Guidance literature:: Multi-step reaction with 5 steps

1: 77 percent / H₂SO₄ / acetic acid / 48 h / Ambient temperature

2: 76 percent / H₂ / Pd/C / dimethylformamide / 7 h

3: 1) NaNO₂, HCl; 2) N-ethylpiperidine / 1) DMF, H₂O, -30 deg C, 10 min; 2) DMF, 12 h, 0 deg C

4: trifluoracetic acid, anisole / 0.17 h / Heating

5: Zerolite FF (acetate cycle) / H₂O / 2 h

With 1-ethyl-piperidine; hydrogenchloride; Zerolite FF (acetate cycle); sulfuric acid; hydrogen; methoxybenzene; trifluoroacetic acid; sodium nitrite; palladium on activated charcoal; In water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1135/cccc19800452

Reference yield:

: 74084-27-8
N-benzyloxycarbonylphenylalanine 3,3',4,4'-tetramethoxybenzhydrylamide

: 74084-34-7
2-oxoimidazolidine-1-carbonyl-histidyl-phenylalanine amide acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 76 percent / H₂ / Pd/C / dimethylformamide / 7 h

2: 1) NaNO₂, HCl; 2) N-ethylpiperidine / 1) DMF, H₂O, -30 deg C, 10 min; 2) DMF, 12 h, 0 deg C

3: trifluoracetic acid, anisole / 0.17 h / Heating

4: Zerolite FF (acetate cycle) / H₂O / 2 h

With 1-ethyl-piperidine; hydrogenchloride; Zerolite FF (acetate cycle); hydrogen; methoxybenzene; trifluoroacetic acid; sodium nitrite; palladium on activated charcoal; In water; N,N-dimethyl-formamide;
DOI:10.1135/cccc19800452

Reference yield:

: 2-oxoimidazolidine-1-carbonyl-histidine methyl ester

: 74084-34-7
2-oxoimidazolidine-1-carbonyl-histidyl-phenylalanine amide acetate

Guidance literature:: Multi-step reaction with 4 steps

1: NH₂NH₂*H₂O / methanol / 48 h / Ambient temperature

2: 1) NaNO₂, HCl; 2) N-ethylpiperidine / 1) DMF, H₂O, -30 deg C, 10 min; 2) DMF, 12 h, 0 deg C

3: trifluoracetic acid, anisole / 0.17 h / Heating

4: Zerolite FF (acetate cycle) / H₂O / 2 h

With 1-ethyl-piperidine; hydrogenchloride; Zerolite FF (acetate cycle); hydrazine hydrate; methoxybenzene; trifluoroacetic acid; sodium nitrite; In methanol; water;
DOI:10.1135/cccc19800452