2-(4-Chloro-2-hydroxyphenoxy)acetic acid

Base Information

• Chemical Name: 2-(4-Chloro-2-hydroxyphenoxy)acetic acid
• CAS No.: 7417-89-2
• Molecular Formula: C8H7ClO4
• Molecular Weight: 202.594
• DSSTox Substance ID: DTXSID20587803
• Nikkaji Number: J1.658.857A
• Wikidata: Q82480299
• Mol file: 7417-89-2.mol

Synonyms:2-(4-Chloro-2-hydroxyphenoxy)acetic acid;7417-89-2;2-(4-Chloro-2-hydroxyphenoxy)aceticacid;2-hydroxy-4-chlorophenoxyacetic acid;SCHEMBL1333513;DTXSID20587803;IJMOEYYLLVJVAS-UHFFFAOYSA-N;4-chloro-2-hydroxyphenoxyacetic acid;MFCD13192100;AKOS016006572;(4-Chloro-2-hydroxyphenoxy)acetic acid;(4-Chloro-2-hydroxyphenoxy)-acetic acid;DS-16529;(4-chloro-2-hydroxy-phenoxy)-acetic acid;DB-329311;CS-0186416;O10479;EN300-1967626

Chemical Property of 2-(4-Chloro-2-hydroxyphenoxy)acetic acid

Chemical Property:

• XLogP3: 1.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 202.0032864
• Heavy Atom Count: 13
• Complexity: 185

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1Cl)O)OCC(=O)O

Technology Process of 2-(4-Chloro-2-hydroxyphenoxy)acetic acid

There total 4 articles about 2-(4-Chloro-2-hydroxyphenoxy)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

ethyl 2-methoxy-4-chlorophenoxyacetate (19048-76-1) → 4-chloro-2-hydroxy phenoxyacetic acid (7417-89-2)

Guidance literature:

With boron tribromide; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1021/jm061368v

Reference yield:

2-(4-chloro-2-methoxyphenoxy) acetic acid (56913-08-7) → 4-chloro-2-hydroxy phenoxyacetic acid (7417-89-2)

Guidance literature:

With hydrogen bromide;

DOI:10.1039/jr9550003681

Reference yield:

2-methoxy-4-nitrophenol (3251-56-7) → 4-chloro-2-hydroxy phenoxyacetic acid (7417-89-2)

Guidance literature:

Multi-step reaction with 3 steps

2: chloroacetic acid; aqueous NaOH

3: aqueous HBr

With sodium hydroxide; hydrogen bromide; chloroacetic acid;

DOI:10.1039/jr9550003681

upstream raw materials:

2-(4-chloro-2-methoxyphenoxy) acetic acid

ethyl 2-methoxy-4-chlorophenoxyacetate

2-methoxy-4-nitrophenol

Downstream raw materials:

(2-hydroxy-4-chlorophenoxy)-N-ethylacetamide

methyl {4-chloro-2-[4-(methylsulfonyl)-3-(trifluoromethyl)phenoxy]phenoxy}acetate

[4-chloro-2-(pyrimidin-5-yloxy)phenoxy]acetic acid

[4-chloro-2-[4-(ethylsulfonyl)phenoxy]phenoxy]-acetic acid sodium salt