2-Amino-1-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-β-L-lyxo-heptopyranosyl)-4-O-methyl-5-methylamino-2,3,5-trideoxy-D-allo-inositol

Base Information

Chemical Name:2-Amino-1-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-β-L-lyxo-heptopyranosyl)-4-O-methyl-5-methylamino-2,3,5-trideoxy-D-allo-inositol
CAS No.:68743-78-2
Molecular Formula:C₁₅H₃₂N₄O₄
Molecular Weight:332.443
Hs Code.:
Mol file:68743-78-2.mol

Synonyms:5-Deoxyfortimycin B;Sporaricin B;KA 6606II;Antibiotic KA 6606II;2-Deoxyfortimycin B;

Suppliers and Price of 2-Amino-1-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-β-L-lyxo-heptopyranosyl)-4-O-methyl-5-methylamino-2,3,5-trideoxy-D-allo-inositol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
SPORARICIN B 95.00%
5MG
$ 505.16

Total 4 raw suppliers

Chemical Property of 2-Amino-1-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-β-L-lyxo-heptopyranosyl)-4-O-methyl-5-methylamino-2,3,5-trideoxy-D-allo-inositol

Chemical Property:

Vapor Pressure:1.16E-11mmHg at 25°C
Boiling Point:490.1°Cat760mmHg
PKA:13.71±0.70(Predicted)
Flash Point:250.2°C
PSA：138.01000
Density:1.19g/cm³
LogP:0.73790

Purity/Quality:

99% ^*data from raw suppliers

SPORARICIN B 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-Amino-1-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-β-L-lyxo-heptopyranosyl)-4-O-methyl-5-methylamino-2,3,5-trideoxy-D-allo-inositol

There total 1 articles about 2-Amino-1-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-β-L-lyxo-heptopyranosyl)-4-O-methyl-5-methylamino-2,3,5-trideoxy-D-allo-inositol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 68743-78-2,71657-28-8,75829-53-7,81738-62-7,81768-56-1,81800-11-5,83648-64-0
3-Amino-2-[3-amino-6-((S)-1-amino-ethyl)-tetrahydro-pyran-2-yloxy]-5-methoxy-6-methylamino-cyclohexanol

Guidance literature:: durch Saccharopolyspora hirsuta subsp. kobensis prod. (isoliert als Monohydrat);
DOI:10.7164/antibiotics.32.173

Reference yield: 90.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 68743-78-2,71657-28-8,75829-53-7,81738-62-7,81768-56-1,81800-11-5,83648-64-0
sporaricin B base

: 74556-46-0,78340-65-5
{(1S,2R,3R,4R,6S)-4-Benzyloxycarbonylamino-3-[(2R,3R,6S)-3-benzyloxycarbonylamino-6-((R)-1-benzyloxycarbonylamino-ethyl)-tetrahydro-pyran-2-yloxy]-2-hydroxy-6-methoxy-cyclohexyl}-methyl-carbamic acid benzyl ester

Guidance literature:: DOI:10.1016/0008-6215(83)88118-X

Reference yield:

: 68743-78-2,71657-28-8,75829-53-7,81738-62-7,81768-56-1,81800-11-5,83648-64-0
sporaricin B base

: 86651-60-7
[({(1R,2R,3R,4R,6S)-4-Amino-3-[(2R,3R,6S)-3-amino-6-((R)-1-amino-ethyl)-tetrahydro-pyran-2-yloxy]-2-fluoro-6-methoxy-cyclohexyl}-methyl-carbamoyl)-methyl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent

2: 31 percent / diethylaminosulfur trifluoride / CH₂Cl₂ / 1.) 15 min, -15 deg C; 2.) 30 min, r.t.

3: 79 percent / 0.2 M hydrochloric acid, hydrogen / 10 percent palladium-on-charcoal / methanol / 4 h / 760 Torr

4: 405 mg / methanol / 1 h / Heating

5: triethylamine / various solvent(s) / 37 °C / Heating

6: 372 mg / 0.2 M hydrochloric acid / H₂O

With hydrogenchloride; diethylamino-sulfur trifluoride; hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; water;
DOI:10.1016/0008-6215(83)88118-X