1H-Pyrazole-4-carboxylic acid, 1-methyl-5-[(2-nitrophenyl)amino]-, ethyl ester

Base Information

Chemical Name:1H-Pyrazole-4-carboxylic acid, 1-methyl-5-[(2-nitrophenyl)amino]-, ethyl ester
CAS No.:74772-07-9
Molecular Formula:C13H14N4O4
Molecular Weight:290.279
Hs Code.:

Synonyms:1-Methyl-5-(2-nitro-phenylamino)-1H-pyrazole-4-carboxylic acid ethyl ester;1-methyl-5-(2-nitro-anilino)-1H-pyrazole-4-carboxylic acid ethyl ester;

Suppliers and Price of 1H-Pyrazole-4-carboxylic acid, 1-methyl-5-[(2-nitrophenyl)amino]-, ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 2 raw suppliers

Chemical Property of 1H-Pyrazole-4-carboxylic acid, 1-methyl-5-[(2-nitrophenyl)amino]-, ethyl ester

Chemical Property:

Melting Point:66 °C(Solv: isopropanol (67-63-0))
Boiling Point:445.5±40.0 °C(Predicted)
PSA：101.97000
Density:1.36±0.1 g/cm3(Predicted)
LogP:2.84480

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of 1H-Pyrazole-4-carboxylic acid, 1-methyl-5-[(2-nitrophenyl)amino]-, ethyl ester

There total 3 articles about 1H-Pyrazole-4-carboxylic acid, 1-methyl-5-[(2-nitrophenyl)amino]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 31037-02-2
ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate

: 1493-27-2,127723-77-7
ortho-nitrofluorobenzene

: 74772-07-9
ethyl 1-methyl-5-<(2-nitrophenyl)amino>-pyrazole-4-carboxylate

Guidance literature:: With sodium hydride; In tetrahydrofuran; for 48h;
DOI:10.1021/acs.jmedchem.8b00697

Reference yield: 58.0%

: 1493-27-2,127723-77-7
ortho-nitrofluorobenzene

: 74772-07-9
ethyl 1-methyl-5-<(2-nitrophenyl)amino>-pyrazole-4-carboxylate

Guidance literature:: ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 0.75h;

ortho-nitrofluorobenzene; In tetrahydrofuran; at 20 ℃; for 18h;

Reference yield:

: 94-05-3,42466-69-3
2-cyano-3-ethoxyacrylic acid ethyl ester

: 74772-07-9
ethyl 1-methyl-5-<(2-nitrophenyl)amino>-pyrazole-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / ethanol

2: 62 percent / NaH / tetrahydrofuran

With sodium hydride; In tetrahydrofuran; ethanol;
DOI:10.1016/j.bmcl.2004.04.107