2-Piperidinecarboxylic acid, 1-[2-[[(1,1-dimethylethoxy)carbonyl]amino]-5-[[imino(nitroamino)methyl] amino]-1-oxopentyl]-4-methyl-, ethyl ester

Base Information

• Chemical Name: 2-Piperidinecarboxylic acid, 1-[2-[[(1,1-dimethylethoxy)carbonyl]amino]-5-[[imino(nitroamino)methyl] amino]-1-oxopentyl]-4-methyl-, ethyl ester
• CAS No.: 74863-81-3
• Molecular Formula: C₂₀H₃₆N₆O₇
• Molecular Weight: 472.542

Synonyms:

Chemical Property of 2-Piperidinecarboxylic acid, 1-[2-[[(1,1-dimethylethoxy)carbonyl]amino]-5-[[imino(nitroamino)methyl] amino]-1-oxopentyl]-4-methyl-, ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Piperidinecarboxylic acid, 1-[2-[[(1,1-dimethylethoxy)carbonyl]amino]-5-[[imino(nitroamino)methyl] amino]-1-oxopentyl]-4-methyl-, ethyl ester

There total 2 articles about 2-Piperidinecarboxylic acid, 1-[2-[[(1,1-dimethylethoxy)carbonyl]amino]-5-[[imino(nitroamino)methyl] amino]-1-oxopentyl]-4-methyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Boc-Arg(NO2)-OH (2188-18-3) → ethyl 1-α-(tert-butoxycarbonyl)-Nω-nitro-L-arginyl>-4-methyl-2-piperidinecarboxylate (74863-81-3,74874-07-0)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 0.25 h / -20 °C

2: tetrahydrofuran / 1.) -20 deg C, 10 min, 2.) RT, 1 h

In tetrahydrofuran;

DOI:10.1021/jm00186a003

Reference yield:

4(R)-Methylpiperidine-2(R)-carboxylic acid ethyl ester (66937-93-7,42205-75-4) + Boc-Arg(NO2G)-OIBC → ethyl 1-α-(tert-butoxycarbonyl)-Nω-nitro-L-arginyl>-4-methyl-2-piperidinecarboxylate (74863-81-3,74874-07-0)

Guidance literature:

In tetrahydrofuran; Yield given; 1.) -20 deg C, 10 min, 2.) RT, 1 h;

DOI:10.1021/jm00186a003

Reference yield:

ethyl 1-α-(tert-butoxycarbonyl)-Nω-nitro-L-arginyl>-4-methyl-2-piperidinecarboxylate (74863-81-3,74874-07-0) → ethyl 4-methyl-1-(Nω-nitro-L-arginyl)piperidinecarboxylate hydrochloride (69129-28-8,74874-08-1)

Guidance literature:

With hydrogenchloride; In ethyl acetate; for 3h;

DOI:10.1021/jm00186a003

upstream raw materials:

4(R)-Methylpiperidine-2(R)-carboxylic acid ethyl ester

Boc-Arg(NO₂)-OH

Downstream raw materials:

ethyl 4-methyl-1-(N^ω-nitro-L-arginyl)piperidinecarboxylate hydrochloride

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