Piperidine, 4-[[2-(trifluoromethyl)phenyl]methyl]-

Base Information

• Chemical Name: Piperidine, 4-[[2-(trifluoromethyl)phenyl]methyl]-
• CAS No.: 749913-50-6
• Molecular Formula: C13H16F3N
• Molecular Weight: 243.272
• Mol file: 749913-50-6.mol

Synonyms:4-(2-(TRIFLUOROMETHYL)BENZYL)PIPERIDINE;4-(2-trifluoromethylbenzyl)piperidine;

Chemical Property of Piperidine, 4-[[2-(trifluoromethyl)phenyl]methyl]-

Chemical Property:

• PSA: 12.03000
• LogP: 3.57630

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Piperidine, 4-[[2-(trifluoromethyl)phenyl]methyl]-

There total 1 articles about Piperidine, 4-[[2-(trifluoromethyl)phenyl]methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-piperidinecarboxylic acid, 4-(2-trifluoromethylphenylmethyl),-1,1-dimethylethyl ester (336182-27-5) → 4-[2-trifluoromethyl-benzyl]-piperidine (749913-50-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield: 18.0%

4-[2-trifluoromethyl-benzyl]-piperidine (749913-50-6) + C14H12O5 (749913-42-6) → C27H28F3NO4

Guidance literature:

4-[2-trifluoromethyl-benzyl]-piperidine; C₁₄H₁₂O₅; With titanium(IV) isopropylate; at 120 ℃;

With sodium tetrahydroborate; In ethanol;

DOI:10.1016/j.bmcl.2004.06.050

Reference yield: 18.0%

4-[2-trifluoromethyl-benzyl]-piperidine (749913-50-6) + C15H14O5 (749913-44-8) → C28H30F3NO4

Guidance literature:

4-[2-trifluoromethyl-benzyl]-piperidine; C₁₅H₁₄O₅; With titanium(IV) isopropylate; at 120 ℃;

With sodium tetrahydroborate; In ethanol;

DOI:10.1016/j.bmcl.2004.06.050

upstream raw materials:

1-piperidinecarboxylic acid, 4-(2-trifluoromethylphenylmethyl),-1,1-dimethylethyl ester