Desethylene Norfloxacin Hydrochloride

Base Information

• Chemical Name: Desethylene Norfloxacin Hydrochloride
• CAS No.: 75001-77-3
• Molecular Formula: C14H16FN3O3
• Molecular Weight: 293.298
• Mol file: 75001-77-3.mol

Synonyms:Desethylene Norfloxacin Hydrochloride;

Chemical Property of Desethylene Norfloxacin Hydrochloride

Chemical Property:

• Melting Point: >242°C (dec.)
• PSA: 74.57000
• LogP: 2.97840
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility.: DMSO (Slightly, Heated), Water (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

Desethylene Norfloxacin Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Desethylene Norfloxacin is a degradation intermediate from Norfloxin (N681000), an fluorinated quinolone antibacterial agent.

Technology Process of Desethylene Norfloxacin Hydrochloride

There total 3 articles about Desethylene Norfloxacin Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

lomefloxacin (98079-51-7) → 8-desfluoro-lomefloxacin (98079-47-1) + 7-(2-aminoethylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (75001-77-3) + 1-ethyl-6-fluoro-1,4dihydro-7-(2-aminopropylamino)-4-oxo-3-quinolinecarboxylic acid + 8-Fluoro-9-(3-methyl-piperazin-1-yl)-6-oxo-1,2-dihydro-6H-pyrrolo[3,2,1-ij]quinoline-5-carboxylic acid (195259-11-1)

Guidance literature:

With 2'-Deoxyguanosine; In aq. phosphate buffer; pH=Ca.7.4; Quantum yield; Irradiation;

DOI:10.1016/j.freeradbiomed.2013.11.027

Reference yield:

lomefloxacin (98079-51-7) → 7-(2-aminoethylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (75001-77-3) + 1-ethyl-6-fluoro-1,4dihydro-7-(2-aminopropylamino)-4-oxo-3-quinolinecarboxylic acid

Guidance literature:

In water; pH=12; Kinetics; Quantum yield; Flash photolysis; Inert atmosphere;

DOI:10.1021/ol301694p

Reference yield:

lomefloxacin (98079-51-7) → 7-(2-aminoethylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (75001-77-3) + 1-ethyl-6-fluoro-1,4dihydro-7-(2-aminopropylamino)-4-oxo-3-quinolinecarboxylic acid + 8-Fluoro-9-(3-methyl-piperazin-1-yl)-6-oxo-1,2-dihydro-6H-pyrrolo[3,2,1-ij]quinoline-5-carboxylic acid (195259-11-1) + 1-Ethyl-6-fluoro-7-(4-methyl-2-oxo-imidazolidin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Guidance literature:

With phosphate buffer; Irradiation;

DOI:10.1039/a703226i

upstream raw materials:

lomefloxacin