Ethyl 4-(6-amino-3-fluoropyridin-2-yl)piperazine-1-carboxylate

Base Information

Chemical Name:Ethyl 4-(6-amino-3-fluoropyridin-2-yl)piperazine-1-carboxylate
CAS No.:75167-28-1
Molecular Formula:C12H17FN4O2
Molecular Weight:268.291
Hs Code.:
DSSTox Substance ID:DTXSID90517435
Nikkaji Number:J133.156F
Wikidata:Q82379446
Mol file:75167-28-1.mol

Synonyms:75167-28-1;ethyl 4-(6-amino-3-fluoropyridin-2-yl)piperazine-1-carboxylate;SCHEMBL10964890;DTXSID90517435

Suppliers and Price of Ethyl 4-(6-amino-3-fluoropyridin-2-yl)piperazine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of Ethyl 4-(6-amino-3-fluoropyridin-2-yl)piperazine-1-carboxylate

Chemical Property:

PSA：72.42000
LogP:1.01440
XLogP3:1.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:268.13355396
Heavy Atom Count:19
Complexity:310

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)N1CCN(CC1)C2=C(C=CC(=N2)N)F

Technology Process of Ethyl 4-(6-amino-3-fluoropyridin-2-yl)piperazine-1-carboxylate

There total 7 articles about Ethyl 4-(6-amino-3-fluoropyridin-2-yl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75167-27-0
6-acetylamino-2-(4-ethoxycarbonyl-1-piperazinyl)-3-fluoropyridine

: 75167-28-1
6-amino-2-(4-ethoxycarbonyl-1-piperazinyl)-3-fluoropyridine

Guidance literature:: With hydrogenchloride; In methanol; for 2h; Heating;
DOI:10.1002/jhet.5570210309

Reference yield:

: 75167-21-4
4-(6-chloro-3-nitro-2-pyridinyl)-1-piperazinecarboxylic acid,ethyl ester

: 75167-28-1
6-amino-2-(4-ethoxycarbonyl-1-piperazinyl)-3-fluoropyridine

Guidance literature:: Multi-step reaction with 6 steps

1: 54.6 percent / 13percent ammonia / ethanol / 15 h / 100 - 110 °C / autoclave

2: 95 percent / acetic acid / 0.5 h / 90 °C

3: zinc powder, acetic acid / ethanol / 0.17 h / Heating

4: 42percent tetrafluoroboric acid, sodium nitrite / ethanol; H₂O / 0.17 h / -7 - -4 °C

5: 82.3 percent / toluene / 4 h / Heating

6: 10percent HCl / methanol / 2 h / Heating

With hydrogenchloride; ammonium hydroxide; tetrafluoroboric acid; acetic acid; zinc; sodium nitrite; In methanol; ethanol; water; acetic acid; toluene;
DOI:10.1002/jhet.5570210309

Reference yield:

: 75167-22-5
4-(6-Amino-3-nitro-pyridin-2-yl)-piperazine-1-carboxylic acid ethyl ester

: 75167-28-1
6-amino-2-(4-ethoxycarbonyl-1-piperazinyl)-3-fluoropyridine

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / acetic acid / 0.5 h / 90 °C

2: zinc powder, acetic acid / ethanol / 0.17 h / Heating

3: 42percent tetrafluoroboric acid, sodium nitrite / ethanol; H₂O / 0.17 h / -7 - -4 °C

4: 82.3 percent / toluene / 4 h / Heating

5: 10percent HCl / methanol / 2 h / Heating

With hydrogenchloride; tetrafluoroboric acid; acetic acid; zinc; sodium nitrite; In methanol; ethanol; water; acetic acid; toluene;
DOI:10.1002/jhet.5570210309