2-Benzoyl-6-nitrobenzoic acid methyl ester

Base Information

• Chemical Name: 2-Benzoyl-6-nitrobenzoic acid methyl ester
• CAS No.: 7531-38-6
• Molecular Formula: C15H11NO5
• Molecular Weight: 285.25200
• Mol file: 7531-38-6.mol

Synonyms:2-Benzoyl-6-nitro-benzoesaeure-methylester;2-Benzoyl-6-nitro-benzoic acid methyl ester;methyl 2-benzoyl-6-nitrobenzoate;

Chemical Property of 2-Benzoyl-6-nitrobenzoic acid methyl ester

Chemical Property:

• Melting Point: 95 - 97 °C
• PSA: 89.19000
• LogP: 3.13560

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Benzoyl-6-nitrobenzoic acid methyl ester

There total 8 articles about 2-Benzoyl-6-nitrobenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + 6-nitro-o-benzoylbenzoic acid (7335-77-5) → 2-benzoyl-6-nitro-benzoic acid methyl ester (7531-38-6)

Guidance literature:

In methanol; diethyl ether; water; for 0.5h; Ambient temperature;

Reference yield:

3-nitro-phthalic acid-1-chloride-2-methyl ester (22351-62-8) → 2-benzoyl-6-nitro-benzoic acid methyl ester (7531-38-6)

Guidance literature:

aluminium trichloride; In methanol; benzene;

Reference yield:

2-(methoxycarbonyl)-3-nitrobenzoic acid (6744-85-0) → 2-benzoyl-6-nitro-benzoic acid methyl ester (7531-38-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Cl(CO)2Cl, DMF / CH₂Cl₂ / Ambient temperature

2: AlCl₃ / Ambient temperature

With aluminium trichloride; oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1021/jo970571i

upstream raw materials:

3-nitro-phthalic acid-1-chloride-2-methyl ester

benzene

diazomethane

3-nitrophthalic acid anhydride

Downstream raw materials:

methyl 6-amino-2-benzoylbenzoate