1,3-Bis[(benzyloxy)methyl]dihydropyrimidine-2,4(1H,3H)-dione

Base Information

Chemical Name:1,3-Bis[(benzyloxy)methyl]dihydropyrimidine-2,4(1H,3H)-dione
CAS No.:75500-05-9
Molecular Formula:C20H22N2O4
Molecular Weight:354.406
Hs Code.:
DSSTox Substance ID:DTXSID00515280
Wikidata:Q82376073

Synonyms:75500-05-9;DTXSID00515280;1,3-Bis[(benzyloxy)methyl]dihydropyrimidine-2,4(1H,3H)-dione

Suppliers and Price of 1,3-Bis[(benzyloxy)methyl]dihydropyrimidine-2,4(1H,3H)-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 1,3-Bis[(benzyloxy)methyl]dihydropyrimidine-2,4(1H,3H)-dione

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:354.15795719
Heavy Atom Count:26
Complexity:459

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(C(=O)N(C1=O)COCC2=CC=CC=C2)COCC3=CC=CC=C3

Technology Process of 1,3-Bis[(benzyloxy)methyl]dihydropyrimidine-2,4(1H,3H)-dione

There total 3 articles about 1,3-Bis[(benzyloxy)methyl]dihydropyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 75499-99-9
N₁,N₃-dibenzyloxymethyl uracil

: 75500-05-9
N¹,N³-Dibenzyloxymethyl-5,6-dihydrouracil

Guidance literature:: With L-Selectride; In tetrahydrofuran; at -78 ℃; for 0.666667h;

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 75500-05-9
N¹,N³-Dibenzyloxymethyl-5,6-dihydrouracil

Guidance literature:: Multi-step reaction with 2 steps

1: anhydrous potassium carbonate / dimethylformamide / Ambient temperature

2: 1.) lithium tri-sec-butyl borohydride; 2.) H₂O / 1.) THF, dry ice-acetone bath, 5-10 min

With water; L-Selectride; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(01)83925-3

Reference yield:

: 504-07-4
5,6-dhydrouracil

: 3587-60-8
Benzyloxymethyl chloride

: 75500-05-9
N¹,N³-Dibenzyloxymethyl-5,6-dihydrouracil

: 97838-63-6
N¹-Benzyloxymethyl-5,6-dihydrouracil

Guidance literature:: With sodium hydride; Yield given. Multistep reaction. Yields of byproduct given; 1.) DMF, room temp., 4 h, 2.) room temp., 7 days;
DOI:10.1055/s-1985-31199