1-Methyl-3-(2-phenylethyl)-2,4(1H,3H)-quinazolinedione

Base Information

Chemical Name:1-Methyl-3-(2-phenylethyl)-2,4(1H,3H)-quinazolinedione
CAS No.:75652-62-9
Molecular Formula:C17H16N2O2
Molecular Weight:280.326
Hs Code.:
DSSTox Substance ID:DTXSID801208241
Nikkaji Number:J2.389.263D
Wikidata:Q105287558

Synonyms:DTXSID801208241;75652-62-9;1-Methyl-3-(2-phenylethyl)-2,4(1H,3H)-quinazolinedione;InChI=1/C17H16N2O2/c1-18-15-10-6-5-9-14(15)16(20)19(17(18)21)12-11-13-7-3-2-4-8-13/h2-10H,11-12H2,1H

Suppliers and Price of 1-Methyl-3-(2-phenylethyl)-2,4(1H,3H)-quinazolinedione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Methyl-3-(2-phenylethyl)-2,4(1H,3H)-quinazolinedione

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:280.121177757
Heavy Atom Count:21
Complexity:404

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN1C2=CC=CC=C2C(=O)N(C1=O)CCC3=CC=CC=C3

Technology Process of 1-Methyl-3-(2-phenylethyl)-2,4(1H,3H)-quinazolinedione

There total 9 articles about 1-Methyl-3-(2-phenylethyl)-2,4(1H,3H)-quinazolinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 1.0%

: 1943-82-4
phenethyl isocyanate

: 10328-92-4
N-Methylisatoic anhydride

: 75652-62-9
1-methyl-3-(2'-phenylethyl)-1H,3H-quinazoline-2,4-dione

Guidance literature:: With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 2-methyltetrahydrofuran; at 60 ℃; for 22h;
DOI:10.1021/acs.orglett.7b00052

Reference yield:

: 610-94-6
2-bromobenzoic acid methyl ester

: 75652-62-9
1-methyl-3-(2'-phenylethyl)-1H,3H-quinazoline-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / Cs₂CO₃; Pd₂(dba)3; xantphos / dioxane / 48 h / 100 °C

2: 98 percent / NaH / dimethylformamide / 0 - 20 °C

With tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; sodium hydride; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/ol062009x

Reference yield:

: 2158-04-5
(2-phenylethyl)urea

: 75652-62-9
1-methyl-3-(2'-phenylethyl)-1H,3H-quinazoline-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / Cs₂CO₃; Pd₂(dba)3; xantphos / dioxane / 48 h / 100 °C

2: 98 percent / NaH / dimethylformamide / 0 - 20 °C

With tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; sodium hydride; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/ol062009x