3-(2-Amino-1-hydroxypropyl)phenol

Base Information

• Chemical Name: 3-(2-Amino-1-hydroxypropyl)phenol
• CAS No.: 7619-17-2
• Molecular Formula: C9H13NO2
• Molecular Weight: 167.208
• DSSTox Substance ID: DTXSID50858992
• Nikkaji Number: J2.367.780F
• Wikipedia: Meta-Hydroxynorephedrine
• Wikidata: Q4847848
• ChEMBL ID: CHEMBL29829
• Mol file: 7619-17-2.mol

Synonyms:3-(2-Amino-1-hydroxypropyl)phenol;7619-17-2;21480-44-4;CHEMBL29829;SCHEMBL3148045;Benzenemethanol, .alpha.-(1-aminoethyl)-3-hydroxy-, (R-(R*,S*))-;DTXSID50858992;AKOS009208228;2-Amino-1-(3-hydroxyphenyl)-1-propanol;LS-42647;FT-0771391;3-(2-Amino-1-hydroxypropyl)phenol-, (-)- #;1-.alpha.-(1-Aminoethyl)-m-hydroxybenzyl alcohol;L001281;Q4847848;(-)-.alpha.-(1-Aminoethyl)-m-hydroxybenzyl alcohol;F2173-0939;Benzyl alcohol, .alpha.-(1-aminoethyl)-m-hydroxy-, (-)-;20890-83-9

Chemical Property of 3-(2-Amino-1-hydroxypropyl)phenol

Chemical Property:

• Boiling Point: 357.9±27.0 °C(Predicted)
• PKA: 9.75±0.10(Predicted)
• Density: 1.198±0.06 g/cm3(Predicted)
• XLogP3: -0.4
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 167.094628657
• Heavy Atom Count: 12
• Complexity: 141

Purity/Quality:

99% ^*data from raw suppliers

3-(2-amino-1-hydroxypropyl)phenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C(C1=CC(=CC=C1)O)O)N

Technology Process of 3-(2-Amino-1-hydroxypropyl)phenol

There total 19 articles about 3-(2-Amino-1-hydroxypropyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(1R,2S)-N-(benzyloxycarbonyl)-2-amino-1-(3-benzooxyphenyl)-1-propanol → (1R,2S)-metaraminol (54-49-9,61-59-6,4956-27-8,7619-17-2,19289-78-2,21480-43-3,21480-44-4,46064-19-1,73952-03-1)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; dichloromethane; under 760.051 Torr;

Reference yield: 79.7%

metaraminol bitartrate → (1R,2S)-metaraminol (54-49-9,61-59-6,4956-27-8,7619-17-2,19289-78-2,21480-43-3,21480-44-4,46064-19-1,73952-03-1)

Guidance literature:

With ammonia; water; at 20 ℃; for 0.5h;

Reference yield:

3-(1-hydroxy-2-nitropropyl)phenol → [3H]-(+/-)-Metaraminol (61-59-6) + (1R,2S)-metaraminol (54-49-9,61-59-6,4956-27-8,7619-17-2,19289-78-2,21480-43-3,21480-44-4,46064-19-1,73952-03-1)

Guidance literature:

With palladium on activated charcoal; hydrogen; In ethanol; at 27 - 35 ℃; for 43h; Temperature; Optical yield = 65 %ee;

upstream raw materials:

meta-hydroxybenzaldehyde

(R)-1-hydroxy-1-(3-hydroxyphenyl)propan-2-one

(+/-)-1-hydroxy-1-(3-hydroxy-phenyl)-acetone oxime

(1RS:2SR)-2-amino-1-(3-benzyloxy-phenyl)-propanol-⁽¹⁾

Downstream raw materials:

6-<18F>fluorometaraminol

6-(acetoxymercurio)-N-t-BOC-metaraminol

(1R,2S)-2-amino-1-(3-hydroxy-4-iodophenyl)-1-propanol

(1R,2S)-2-(tert-butoxycarbonylamino)-1-(3-hydroxyphenyl)-1-propanol