(2R)-1,2,3,4,4a,5,6,8aβ-Octahydro-4aα,8-dimethyl-β-methylene-2α-naphthaleneethanol

Base Information

• Chemical Name: (2R)-1,2,3,4,4a,5,6,8aβ-Octahydro-4aα,8-dimethyl-β-methylene-2α-naphthaleneethanol
• CAS No.: 65018-15-7
• Molecular Formula: C₁₅H₂₄O
• Molecular Weight: 220.355

Synonyms:2-Naphthaleneethanol,1,2,3,4,4a,5,6,8a-octahydro-4a,8-dimethyl-b-methylene-, [2R-(2a,4aa,8ab)]-; (-)-a-Costol; a-Costol

Chemical Property of (2R)-1,2,3,4,4a,5,6,8aβ-Octahydro-4aα,8-dimethyl-β-methylene-2α-naphthaleneethanol

Chemical Property:

• Boiling Point: 314.4±21.0 °C(Predicted)
• PKA: 14.75±0.10(Predicted)
• PSA: 20.23000
• Density: 0.968±0.06 g/cm3(Predicted)
• LogP: 3.69760

Purity/Quality:

ALPHA-COSTOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: α-Costol is an essential oil extracted from flower, leaves and fruits of plants and exhibits phytochemical, antioxidant and antimicrobial activities

Technology Process of (2R)-1,2,3,4,4a,5,6,8aβ-Octahydro-4aα,8-dimethyl-β-methylene-2α-naphthaleneethanol

There total 14 articles about (2R)-1,2,3,4,4a,5,6,8aβ-Octahydro-4aα,8-dimethyl-β-methylene-2α-naphthaleneethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

methyl 2-[(2R,4aR,8aR)-4a,8-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalen-2-yl]acrylate → 2-(2R,4aR,8aR)-(4a,8-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalen-2-yl)prop-2-en-1-ol (65018-15-7)

Guidance literature:

With diisobutylaluminium hydride; In cyclohexane; toluene; at -20 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.tet.2014.12.061

Reference yield: 48.0%

7α-(1-cyanoethenyl)-1,4aβ-dimethyl-3,4,4a,5,6,7,8,8aα-octahydronaphthalene (104106-65-2,104106-66-3) → 2-((2S,4aR,8aR)-4a,8-Dimethyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-2-yl)-prop-2-en-1-ol (65018-15-7)

Guidance literature:

With dibutylaluminum hydride; In toluene; for 3h;

DOI:10.1016/S0040-4039(00)94966-9

Reference yield:

germacra-1(10),4,11(13)-trien-12-ol (347377-91-7) → (+)-β-costol (69427-73-2,72057-07-9,77171-51-8,97371-99-8,515-20-8) + γ-costol (65018-14-6) + 2-(2R,4aR,8aR)-(4a,8-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalen-2-yl)prop-2-en-1-ol (65018-15-7)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; at 20 ℃; for 0.116667h;

DOI:10.1016/S0031-9422(01)00291-6

upstream raw materials:

7α-(1-cyanoethenyl)-1,4aβ-dimethyl-3,4,4a,5,6,7,8,8aα-octahydronaphthalene

2-methylcyclohexane-1,3-dione

4-penten-3-one

(+/-)-3,4,8,8a-tetrahydro-5,8a-dimethyl-1,6(2H,7H)-naphthalenedione

Downstream raw materials:

2-[(2R,4aR,8aR)-4a,8-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalen-2-yl]acrylaldehyde

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 65018-15-7 (2R)-1,2,3,4,4a,5,6,8aβ-Octahydro-4aα,8-dimethyl-β-methylene-2α-naphthaleneethanol

Send

Send

Metric Ton KG G Pound L ML

Send

Send