Technology Process of 2,7,9-Undecatrienoic acid,
11-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-6-ethyl-, methyl ester, (E,E,E)-
There total 9 articles about 2,7,9-Undecatrienoic acid,
11-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-6-ethyl-, methyl ester, (E,E,E)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 1.) LDA, 2.) HMPA / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 6 h
2: 100 percent / diisobutylaluminum hydride / CH2Cl2; toluene / 1 h / -78 °C
3: 70 percent / imidazole / dimethylformamide / 1.5 h / 0 - 20 °C
4: 1.) LDA / 1.) THF, hexane, -78 deg C, 10 min, 2.) THF, hexane, from 0 deg C to 25 deg C, 2 h
5: diisobutylaluminum hydride / CH2Cl2; tetrahydrofuran / 1 h / -78 °C
6: imidazole / dimethylformamide / 1 h / Ambient temperature
7: aq. AcOH / tetrahydrofuran / 1 h / 25 °C
8: pyridinium chlorochromate / CH2Cl2 / 2 h / Ambient temperature
9: toluene / 12 h / 25 °C
With
1H-imidazole; N,N,N,N,N,N-hexamethylphosphoric triamide; diisobutylaluminium hydride; acetic acid; pyridinium chlorochromate; lithium diisopropyl amide;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00209a017
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 100 percent / diisobutylaluminum hydride / CH2Cl2; toluene / 1 h / -78 °C
2: 70 percent / imidazole / dimethylformamide / 1.5 h / 0 - 20 °C
3: 1.) LDA / 1.) THF, hexane, -78 deg C, 10 min, 2.) THF, hexane, from 0 deg C to 25 deg C, 2 h
4: diisobutylaluminum hydride / CH2Cl2; tetrahydrofuran / 1 h / -78 °C
5: imidazole / dimethylformamide / 1 h / Ambient temperature
6: aq. AcOH / tetrahydrofuran / 1 h / 25 °C
7: pyridinium chlorochromate / CH2Cl2 / 2 h / Ambient temperature
8: toluene / 12 h / 25 °C
With
1H-imidazole; diisobutylaluminium hydride; acetic acid; pyridinium chlorochromate; lithium diisopropyl amide;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00209a017
- Guidance literature:
-
Multi-step reaction with 5 steps
1: diisobutylaluminum hydride / CH2Cl2; tetrahydrofuran / 1 h / -78 °C
2: imidazole / dimethylformamide / 1 h / Ambient temperature
3: aq. AcOH / tetrahydrofuran / 1 h / 25 °C
4: pyridinium chlorochromate / CH2Cl2 / 2 h / Ambient temperature
5: toluene / 12 h / 25 °C
With
1H-imidazole; diisobutylaluminium hydride; acetic acid; pyridinium chlorochromate;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00209a017
