4'-FLUORO-2-HYDROXYCHALCONE

Base Information

• Chemical Name: 4'-FLUORO-2-HYDROXYCHALCONE
• CAS No.: 76626-08-9
• Molecular Formula: C15H11FO2
• Molecular Weight: 242.25
• Hs Code.: 2914500090
• Mol file: 76626-08-9.mol

Synonyms:4'-FLUORO-2-HYDROXYCHALCONE;

Chemical Property of 4'-FLUORO-2-HYDROXYCHALCONE

Chemical Property:

• PSA: 37.30000
• LogP: 3.42740

Purity/Quality:

99% ^*data from raw suppliers

4''-Fluoro-2-hydroxychalcone ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4''-Fluoro-2-hydroxychalcone

Technology Process of 4'-FLUORO-2-HYDROXYCHALCONE

There total 1 articles about 4'-FLUORO-2-HYDROXYCHALCONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-(4-fluorophenyl)ethanone (403-42-9) + salicylaldehyde (90-02-8) → 1-(4-fluorophenyl)-3-(2-hydroxyphenyl)prop-2-en-1-one (76626-08-9)

Guidance literature:

With sodium hydroxide; In ethanol; Ambient temperature;

DOI:10.1080/00397919708004094

Reference yield: 98.0%

1-(4-fluorophenyl)-3-(2-hydroxyphenyl)prop-2-en-1-one (76626-08-9) → 1H-4,5-dihydro-3-(4-fluorophenyl)-5-(2-hydroxyphenyl)pyrazole (138840-92-3)

Guidance literature:

With hydrazine hydrate; In ethanol; for 5h; Heating;

DOI:10.1080/00397919708004094

Reference yield: 93.0%

2,3-dihydro-3-oxo-1H-isoindole-1-carboxylic acid ethyl ester (20361-10-8) + 1-(4-fluorophenyl)-3-(2-hydroxyphenyl)prop-2-en-1-one (76626-08-9) → C26H20FNO4

Guidance literature:

With toluene-4-sulfonic acid; In acetonitrile; at 35 ℃; for 48h;

upstream raw materials:

1-(4-fluorophenyl)ethanone

salicylaldehyde

Downstream raw materials:

1H-4,5-dihydro-3-(4-fluorophenyl)-5-(2-hydroxyphenyl)pyrazole

2-(4-fluorophenyl)-4H-chromen-4-one

2-amino-4-[2-(4-fluorophenyl)-2-oxoethyl]-4H-chromene-3-carbonitrile

[2-(4-fluorophenyl)-4H-chromen-4-yl]malononitrile