L-Phenylalanine, 4-amino-3,5-dibromo-

Base Information

• Chemical Name: L-Phenylalanine, 4-amino-3,5-dibromo-
• CAS No.: 76912-54-4
• Molecular Formula: C₉H₁₀Br₂N₂O₂
• Molecular Weight: 337.999
• Mol file: 76912-54-4.mol

Synonyms:

Chemical Property of L-Phenylalanine, 4-amino-3,5-dibromo-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-Phenylalanine, 4-amino-3,5-dibromo-

There total 1 articles about L-Phenylalanine, 4-amino-3,5-dibromo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

4-amino-L-phenylalanine (943-80-6) → L-3-(4'-amino-3',5'-dibromophenyl)alanine (76912-54-4)

Guidance literature:

With bromine; In water; acetic acid; 1.) r.t., 90 min; 75 deg C, 20 min;

DOI:10.1002/hlca.19830660329

Reference yield:

L-3-(4'-amino-3',5'-dibromophenyl)alanine (76912-54-4) → N-[(1,1-dimethylethoxy)carbonyl]-3,5-dibromo-L-tyrosine (58960-71-7,349535-07-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaNO₂, 2 N HBr; 2.) ion-exchange resin Dowex 50 W-8 / 1.) Sandmeyer catalyst / 1.) water, 40 deg C, 30 min

2: 5.3 percent / 1 N NaOH / 2-methyl-propan-2-ol; H₂O / 24 h / Ambient temperature

With sodium hydroxide; ion-exchange resin Dowex 50 W-8; hydrogen bromide; sodium nitrite; Sandmeyer catalyst; In water; tert-butyl alcohol;

DOI:10.1002/hlca.19830660329

Reference yield:

L-3-(4'-amino-3',5'-dibromophenyl)alanine (76912-54-4) → N-(t-butoxycarbonyl)-3-(3',5'-dibromo-4'-chlorophenyl)alanine

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaNO₂, 6 N HCl; 2.) ion-exchange resin Dowex 50 W-8 / 1.) Sandmeyer catalyst / 1.) water, r.t., overnight

2: 22.6 percent / 1 N NaOH, 2 N Na₂CO₃ / 2-methyl-propan-2-ol; H₂O / 16 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; ion-exchange resin Dowex 50 W-8; sodium carbonate; sodium nitrite; Sandmeyer catalyst; In water; tert-butyl alcohol;

DOI:10.1002/hlca.19830660329

upstream raw materials:

4-amino-L-phenylalanine

Downstream raw materials:

L-3-(3',5'-dibromo-4'-chlorophenyl)alanine

L-3-(3',4',5'-tribromophenyl)alanine

N-[(1,1-dimethylethoxy)carbonyl]-3,5-dibromo-L-tyrosine