Cyclohexaneacetic acid, a-methylene-, ethyl ester

Base Information

• Chemical Name: Cyclohexaneacetic acid, a-methylene-, ethyl ester
• CAS No.: 7697-58-7
• Molecular Formula: C11H18O2
• Molecular Weight: 182.263
• Mol file: 7697-58-7.mol

Synonyms:2-Cyclohexyl-acrylic acid ethyl ester;2-Cyclohexyl-propensaeure-aethylester;ethyl 2-cyclohexylacrylate;ethyl 2-cyclohexylpropenoate;2-Cyclohexyl-acrylsaeure-aethylester;

Chemical Property of Cyclohexaneacetic acid, a-methylene-, ethyl ester

Chemical Property:

• Boiling Point: 115 °C(Press: 20 Torr)
• PSA: 26.30000
• Density: 0.966±0.06 g/cm3(Predicted)
• LogP: 2.68600

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclohexaneacetic acid, a-methylene-, ethyl ester

There total 11 articles about Cyclohexaneacetic acid, a-methylene-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

Ethyl hydrogen 2-cyclohexylpropanedioate (147596-63-2,144569-86-8) → Ethyl 2-cyclohexylprop-2-enoate (7697-58-7)

Guidance literature:

With formaldehyd; sodium acetate; acetic acid; N-methylaniline; a) 20 deg C, 1 h, b) 100 deg C, 15 min;

DOI:10.1080/00397919308009804

Reference yield: 72.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + Ethyl hydrogen 2-cyclohexylpropanedioate (147596-63-2,144569-86-8) → Ethyl 2-cyclohexylprop-2-enoate (7697-58-7)

Guidance literature:

With piperidine; pyridine; Heating;

DOI:10.1039/a607170h

Reference yield: 13.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + ethyl 2-cyclohexylacetate (5452-75-5) → Ethyl 2-cyclohexylprop-2-enoate (7697-58-7)

Guidance literature:

ethyl 2-cyclohexylacetate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h;

formaldehyd; at 20 ℃; for 12h;

DOI:10.1021/ja2092689

upstream raw materials:

diethyl 2-cyclohexylmalonate

Ethyl hydrogen 2-cyclohexylpropanedioate

Diazoethan

α-cyclohexylacrylic acid

Downstream raw materials:

(S)-ethyl 2-cyclohexyl-4-oxobutanoate

Ethyl 2-cyclohexylpropionate

4-Cyclohexyl-2-(ethoxycarbonyl)pentandisaeure-diethylester

α-cyclohexylacrylic acid