Methyl-(-)-5S,6S)-epoxy 7-hydroxyheptanoate

Base Information

Chemical Name:Methyl-(-)-5S,6S)-epoxy 7-hydroxyheptanoate
CAS No.:77341-36-7
Molecular Formula:C₈H₁₄O₄
Molecular Weight:174.197
Hs Code.:
DSSTox Substance ID:DTXSID60445998
Nikkaji Number:J1.237.336H
Wikidata:Q82264555

Synonyms:73957-99-0;77341-36-7;METHYL-(-)-5S,6S)-EPOXY 7-HYDROXYHEPTANOATE;Methyl 4-[(2S,3S)-3-(hydroxymethyl)oxiran-2-yl]butanoate;methyl 4-((2S,3S)-3-(hydroxymethyl)oxiran-2-yl)butanoate;CTK2G0261;DTXSID60445998;MFCD00055584;AKOS006272655;METHYL-(-)-5S,6S)-EPOXY7-HYDROXYHEPTANOATE;(2S)-3alpha-(Hydroxymethyl)oxirane-2beta-butyric acid methyl ester

Suppliers and Price of Methyl-(-)-5S,6S)-epoxy 7-hydroxyheptanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of Methyl-(-)-5S,6S)-epoxy 7-hydroxyheptanoate

Chemical Property:

XLogP3:-0.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:174.08920892
Heavy Atom Count:12
Complexity:157

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC(=O)CCCC1C(O1)CO
Isomeric SMILES:COC(=O)CCC[C@H]1[C@@H](O1)CO

Technology Process of Methyl-(-)-5S,6S)-epoxy 7-hydroxyheptanoate

There total 15 articles about Methyl-(-)-5S,6S)-epoxy 7-hydroxyheptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 73957-98-9
C₂₉H₃₀O₉S

: 73957-99-0,77341-36-7,77519-23-4,79356-62-0,79356-66-4,114530-61-9,127760-14-9
(+/-)-methyl trans-5,6-epoxy-7-hydroxyheptanoate

Guidance literature:: With potassium carbonate; In methanol; at 23 ℃; for 2h;
DOI:10.1021/ja00524a045

Reference yield: 77.0%

: 76871-77-7
cis-7-hydroxy-5-heptenoic acid,methyl ester

: 73957-99-0,77341-36-7,77519-23-4,79356-62-0,79356-66-4,114530-61-9,127760-14-9
(+/-)-methyl trans-5,6-epoxy-7-hydroxyheptanoate

Guidance literature:: With 3-chlorobenzoate; In dichloromethane; at 23 ℃; for 14h;
DOI:10.1016/S0040-4039(00)92873-9

Reference yield:

: 55797-81-4,105453-39-2
C₂₆H₂₂O₈

: 73957-99-0,77341-36-7,77519-23-4,79356-62-0,79356-66-4,114530-61-9,127760-14-9
(+/-)-methyl trans-5,6-epoxy-7-hydroxyheptanoate

Guidance literature:: Multi-step reaction with 7 steps

1: 96 percent / benzoic acid / 1,2-dimethoxy-ethane / 4 h / Heating

2: 100 percent / H₂SO₄ / 3 h / 23 °C

3: 93 percent / 95percent zinc amalgam, dry hydrogen chloride / diethyl ether / 6 h / 15 °C

4: 100 percent / H₂ / 10percent Pd/C / methanol / 23 °C

5: 99 percent / dry hydroden chloride / 72 h / 23 °C

6: 98 percent / pyridine / 1.) 23 deg C, 6 h, 2.) 50 deg C, 3h

7: 98 percent / K₂CO₃ / methanol / 2 h / 23 °C

With pyridine; hydrogenchloride; amalgamated zinc; sulfuric acid; hydrogen; potassium carbonate; benzoic acid; palladium on activated charcoal; In methanol; 1,2-dimethoxyethane; diethyl ether;
DOI:10.1021/ja00524a045