Benzaldehyde, 3-chloro-4-hydroxy-6-methoxy-2-methyl-

Base Information

• Chemical Name: Benzaldehyde, 3-chloro-4-hydroxy-6-methoxy-2-methyl-
• CAS No.: 777090-48-9
• Molecular Formula: C9H9ClO3
• Molecular Weight: 200.622
• Mol file: 777090-48-9.mol

Synonyms:

Chemical Property of Benzaldehyde, 3-chloro-4-hydroxy-6-methoxy-2-methyl-

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzaldehyde, 3-chloro-4-hydroxy-6-methoxy-2-methyl-

There total 6 articles about Benzaldehyde, 3-chloro-4-hydroxy-6-methoxy-2-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

3-chloro-6-methoxy-4-methoxymethoxy-2-methyl-benzaldehyde (878480-11-6) → 3-chloro-4-hydroxy-6-methoxy-2-methylbenzaldehyde (777090-48-9)

Guidance literature:

With hydrogenchloride; In methanol;

DOI:10.1002/jhet.5570430105

Reference yield:

1,3-dimethoxy-5-methylbenzene (4179-19-5) → 3-chloro-4-hydroxy-6-methoxy-2-methylbenzaldehyde (777090-48-9)

Guidance literature:

Multi-step reaction with 6 steps

1: 90 percent / phosphoryl chloride / 70 - 80 °C

2: 75 percent / N-chlorosuccinimide / dimethylformamide

3: 95 percent / boron tribromide / CH₂Cl₂

4: 99 percent / i-Pr₂NC₂H₅ / CH₂Cl₂

5: 92 percent / K₂CO₃ / acetone

6: 57 percent / conc. HCl / methanol

With hydrogenchloride; N-chloro-succinimide; boron tribromide; potassium carbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone; 1: Vilsmeier formylation;

DOI:10.1002/jhet.5570430105

Reference yield:

2,4-dimethoxy-6-methyl-benzaldehyde (7149-90-8) → 3-chloro-4-hydroxy-6-methoxy-2-methylbenzaldehyde (777090-48-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 75 percent / N-chlorosuccinimide / dimethylformamide

2: 95 percent / boron tribromide / CH₂Cl₂

3: 99 percent / i-Pr₂NC₂H₅ / CH₂Cl₂

4: 92 percent / K₂CO₃ / acetone

5: 57 percent / conc. HCl / methanol

With hydrogenchloride; N-chloro-succinimide; boron tribromide; potassium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone;

DOI:10.1002/jhet.5570430105

upstream raw materials:

3-chloro-6-methoxy-4-methoxymethoxy-2-methyl-benzaldehyde

1,3-dimethoxy-5-methylbenzene

2,4-dimethoxy-6-methyl-benzaldehyde

3-chloro-4,6-dihydroxy-2-methyl-benzaldehyde

Downstream raw materials:

3-chloro-6-methoxy-2-methyl-4-(3,7-dimethyloct-6-en-1-yn-3-yl)oxybenzaldehyde

3-chloro-4-(1,1-dimethyl-prop-2-ynyloxy)-6-methoxy-2-methyl-benzaldehyde

Refernces

• 1、 Yamaguchi, Seiji,Maekawa, Mikiko,Murayama, Yohei,Miyazawa, Masahiro,Hirai, Yoshiro. "New approach for two chromene carboxylic acids having a fully substituted benzene ring". . p. 6971 - 6973. Retrieved 2007/10/03.