(Z)-3-(4-Sulfamoylphenylcarbamoyl)acrylic acid

Base Information

• Chemical Name: (Z)-3-(4-Sulfamoylphenylcarbamoyl)acrylic acid
• CAS No.: 1886-79-9
• Molecular Formula: C₁₀H₁₀N₂O₅S
• Molecular Weight: 270.266
• Hs Code.: 2935009090
• NSC Number: 163484
• Nikkaji Number: J2.435.142D
• ChEMBL ID: CHEMBL367059
• Mol file: 1886-79-9.mol

Synonyms:(Z)-3-(4-Sulfamoylphenylcarbamoyl)acrylic acid;NSC 66206;CHEMBL367059;NSC163484;40266-10-2;(E)-4-oxo-4-(4-sulfamoylanilino)but-2-enoic acid;3-(4-Sulfamoylphenylcarbamoyl)acrylic acid;NSC66206;SCHEMBL5177092;SCHEMBL5481896;HMS1677A15;BDBM50056850;AKOS000568542;NSC-163484;(E)-3-(4-Sulfamoyl-phenylcarbamoyl)-acrylic acid;4-{[4-(aminosulfonyl)phenyl]amino}-4-oxo-2-butenoic acid

Chemical Property of (Z)-3-(4-Sulfamoylphenylcarbamoyl)acrylic acid

Chemical Property:

• Refractive Index: 1.65
• PSA: 134.94000
• Density: 1.564 g/cm³
• LogP: 1.76740
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 4
• Exact Mass: 270.03104260
• Heavy Atom Count: 18
• Complexity: 443

Purity/Quality:

98%min ^*data from raw suppliers

Maleylsulfanilamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1NC(=O)C=CC(=O)O)S(=O)(=O)N
• Isomeric SMILES: C1=CC(=CC=C1NC(=O)/C=C/C(=O)O)S(=O)(=O)N
• Uses: Maleylsulfanilamide is a compound that may have inhibition properties against human carbonic anhydrase I and II isoenzymes.

Technology Process of (Z)-3-(4-Sulfamoylphenylcarbamoyl)acrylic acid

There total 2 articles about (Z)-3-(4-Sulfamoylphenylcarbamoyl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

maleic anhydride (108-31-6) + sulfanilamide (63-74-1) → N-(4-sulfamoyl-phenyl)-malamic acid (1886-79-9)

Guidance literature:

at 20 ℃;

DOI:10.3109/14756366.2015.1071808

Reference yield:

→ N-(4-sulfamoyl-phenyl)-malamic acid (1886-79-9)

Guidance literature:

Maleinsaeureanhydrid, Sulfanilamid, Acn., einige h bei Raumtemp. Ruehren;

Reference yield:

N-(4-sulfamoyl-phenyl)-malamic acid (1886-79-9) → 4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzenesulfonamide (7300-97-2) + N-(4-sulfamoyl-phenyl)-malamic acid ethyl ester

Guidance literature:

With ethanol; sulfuric acid;

DOI:10.1021/jo01199a004

upstream raw materials:

maleic anhydride

sulfanilamide

Downstream raw materials:

4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzenesulfonamide