8-fluoro-5-(4-fluorophenyl)-1-[2-(1-pyrrolidinyl)ethyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

Base Information

Chemical Name:8-fluoro-5-(4-fluorophenyl)-1-[2-(1-pyrrolidinyl)ethyl]-2,3,4,5-tetrahydro-1H-1-benzazepine
CAS No.:77795-99-4
Molecular Formula:C22H26F2N2
Molecular Weight:356.45200
Hs Code.:
Mol file:77795-99-4.mol

Synonyms:8-Fluoro-5-(4-fluoro-phenyl)-1-(2-pyrrolidin-1-yl-ethyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepine;

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8-fluoro-5-(4-fluorophenyl)-1-[2-(1-pyrrolidinyl)ethyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

Chemical Property:

PSA：6.48000
LogP:4.79560

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 8-fluoro-5-(4-fluorophenyl)-1-[2-(1-pyrrolidinyl)ethyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

There total 3 articles about 8-fluoro-5-(4-fluorophenyl)-1-[2-(1-pyrrolidinyl)ethyl]-2,3,4,5-tetrahydro-1H-1-benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 77795-93-8
2-Diethylamino-1-[8-fluoro-5-(4-fluoro-phenyl)-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl]-ethanone

: 77795-99-4
8-fluoro-5-(4-fluorophenyl)-1-(2-pyrrolidinoethyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; benzene; for 7h; Heating;
DOI:10.1135/cccc19810148

Reference yield:

: 68351-39-3
8-fluoro-5-(4-fluorophenyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

: 77795-99-4
8-fluoro-5-(4-fluorophenyl)-1-(2-pyrrolidinoethyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / K₂CO₃ / CHCl₃ / 1 h / Heating

2: 79 percent / benzene / 9 h / Heating

3: 100 percent / LiAlH₄ / benzene; diethyl ether / 7 h / Heating

With lithium aluminium tetrahydride; potassium carbonate; In diethyl ether; chloroform; benzene;
DOI:10.1135/cccc19810148

Reference yield:

: 77795-92-7
1-(chloroacetyl)-8-fluoro-5-(4-fluorophenyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

: 77795-99-4
8-fluoro-5-(4-fluorophenyl)-1-(2-pyrrolidinoethyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / benzene / 9 h / Heating

2: 100 percent / LiAlH₄ / benzene; diethyl ether / 7 h / Heating

With lithium aluminium tetrahydride; In diethyl ether; benzene;
DOI:10.1135/cccc19810148