Benzoic acid, 3-[1-[(1R,3S)-3-(1-methylethyl)-3-[[6-(trifluoromethyl)-2H-1,3-benzoxazin -3(4H)-yl]carbonyl]cyclopentyl]-4-piperidinyl]-, ethyl ester

Base Information

Chemical Name:Benzoic acid, 3-[1-[(1R,3S)-3-(1-methylethyl)-3-[[6-(trifluoromethyl)-2H-1,3-benzoxazin -3(4H)-yl]carbonyl]cyclopentyl]-4-piperidinyl]-, ethyl ester
CAS No.:782492-14-2
Molecular Formula:C32H39F3N2O4
Molecular Weight:572.668
Hs Code.:

Benzoic acid,
3-[1-[(1R,3S)-3-(1-methylethyl)-3-[[6-(trifluoromethyl)-2H-1,3-benzoxazin
-3(4H)-yl]carbonyl]cyclopentyl]-4-piperidinyl]-, ethyl ester

Synonyms:

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Chemical Property of Benzoic acid, 3-[1-[(1R,3S)-3-(1-methylethyl)-3-[[6-(trifluoromethyl)-2H-1,3-benzoxazin -3(4H)-yl]carbonyl]cyclopentyl]-4-piperidinyl]-, ethyl ester

Chemical Property:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Benzoic acid, 3-[1-[(1R,3S)-3-(1-methylethyl)-3-[[6-(trifluoromethyl)-2H-1,3-benzoxazin -3(4H)-yl]carbonyl]cyclopentyl]-4-piperidinyl]-, ethyl ester

There total 7 articles about Benzoic acid, 3-[1-[(1R,3S)-3-(1-methylethyl)-3-[[6-(trifluoromethyl)-2H-1,3-benzoxazin -3(4H)-yl]carbonyl]cyclopentyl]-4-piperidinyl]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 782493-17-8
(3S)-3-isopropyl-3-{[6-(trifluoromethyl)-2H-1,3-benzoxazin-3(4H)-yl]carbonyl}cyclopentanone

: 782493-23-6
3-piperidin-4-yl-benzoic acid ethyl ester hydrochloride salt

: 782492-14-2
cis ethyl 3-[1-((1R,3S)-3-isopropyl-3-{[6-(trifluoromethyl)-2H-1,3-benzoxazin-3(4H)-yl]carbonyl}cyclopentyl)piperidin-4-yl]benzoate

: trans (ethyl 3-[1-((1R,3S)-3-isopropyl-3-{[6-(trifluoromethyl)-2H-1,3-benzoxazin-3(4H)-yl]carbonyl}cyclopentyl)piperidin-4-yl]benzoate)

Guidance literature:: With sodium tris(acetoxy)borohydride; triethylamine; In 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; at 20 ℃; for 120h;

Reference yield:

: 782493-24-7
ethyl tert-butyl 4-(3-(ethoxycarbonyl)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate

: 782492-14-2
cis ethyl 3-[1-((1R,3S)-3-isopropyl-3-{[6-(trifluoromethyl)-2H-1,3-benzoxazin-3(4H)-yl]carbonyl}cyclopentyl)piperidin-4-yl]benzoate

: trans (ethyl 3-[1-((1R,3S)-3-isopropyl-3-{[6-(trifluoromethyl)-2H-1,3-benzoxazin-3(4H)-yl]carbonyl}cyclopentyl)piperidin-4-yl]benzoate)

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium(II) hydroxide/carbon / methanol / 18 h

2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3: sodium tris(acetoxy)borohydride; triethylamine / dichloromethane / 120 h / 20 °C / Molecular sieve

With hydrogenchloride; hydrogen; sodium tris(acetoxy)borohydride; triethylamine; palladium(II) hydroxide/carbon; In 1,4-dioxane; methanol; dichloromethane;

Reference yield:

: 4334-87-6
[3-(ethoxycarbonyl)phenyl]boronic acid

: 782492-14-2
cis ethyl 3-[1-((1R,3S)-3-isopropyl-3-{[6-(trifluoromethyl)-2H-1,3-benzoxazin-3(4H)-yl]carbonyl}cyclopentyl)piperidin-4-yl]benzoate

: trans (ethyl 3-[1-((1R,3S)-3-isopropyl-3-{[6-(trifluoromethyl)-2H-1,3-benzoxazin-3(4H)-yl]carbonyl}cyclopentyl)piperidin-4-yl]benzoate)

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 3.5 h / Heating / reflux

2: hydrogen / palladium(II) hydroxide/carbon / methanol / 18 h

3: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

4: sodium tris(acetoxy)borohydride; triethylamine / dichloromethane / 120 h / 20 °C / Molecular sieve

With hydrogenchloride; hydrogen; sodium tris(acetoxy)borohydride; sodium carbonate; triethylamine; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium(II) hydroxide/carbon; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water;