Technology Process of Benzoic acid,
3-[(3R,4S)-3-methyl-1-[(1R,3S)-3-(1-methylethyl)-3-[[6-(trifluoromethyl)-
2H-1,3-benzoxazin-3(4H)-yl]carbonyl]cyclopentyl]-4-piperidinyl]-, ethyl
ester
There total 10 articles about Benzoic acid,
3-[(3R,4S)-3-methyl-1-[(1R,3S)-3-(1-methylethyl)-3-[[6-(trifluoromethyl)-
2H-1,3-benzoxazin-3(4H)-yl]carbonyl]cyclopentyl]-4-piperidinyl]-, ethyl
ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium triacetoxyborohydride; N-ethyl-N,N-diisopropylamine;
at 20 ℃;
for 96h;
Molecular sieve;
DOI:10.1021/ml900009d
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: hydrogen / palladium(II) hydroxide/carbon / methanol / 18 h
2.1: sodium periodate; ruthenium tetroxide / chloroform; water / 264 h / 20 °C
3.1: potassium hexamethylsilazane / tetrahydrofuran / 0.5 h / -78 °C
3.2: -78 - 20 °C
4.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C
5.1: dimethylsulfide borane complex / tetrahydrofuran / 72 h / 4 - 20 °C
5.2: 4 h / 50 °C
6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h
6.2: 96 h / 20 °C / Molecular sieve
With
hydrogenchloride; sodium periodate; ruthenium tetroxide; dimethylsulfide borane complex; hydrogen; potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine;
palladium(II) hydroxide/carbon;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; water;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 3.5 h / Heating / reflux
2.1: hydrogen / palladium(II) hydroxide/carbon / methanol / 18 h
3.1: sodium periodate; ruthenium tetroxide / chloroform; water / 264 h / 20 °C
4.1: potassium hexamethylsilazane / tetrahydrofuran / 0.5 h / -78 °C
4.2: -78 - 20 °C
5.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C
6.1: dimethylsulfide borane complex / tetrahydrofuran / 72 h / 4 - 20 °C
6.2: 4 h / 50 °C
7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h
7.2: 96 h / 20 °C / Molecular sieve
With
hydrogenchloride; sodium periodate; ruthenium tetroxide; dimethylsulfide borane complex; hydrogen; potassium hexamethylsilazane; sodium carbonate; N-ethyl-N,N-diisopropylamine; lithium chloride;
tetrakis(triphenylphosphine) palladium(0); palladium(II) hydroxide/carbon;
In
tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; chloroform; water;
