N-(4-Chloro-2-iodophenyl)-2,2,2-trifluoroacetamide

Base Information

Chemical Name:N-(4-Chloro-2-iodophenyl)-2,2,2-trifluoroacetamide
CAS No.:784183-51-3
Molecular Formula:C8H4ClF3INO
Molecular Weight:349.479
Hs Code.:
DSSTox Substance ID:DTXSID70478156
Nikkaji Number:J2.565.297E
Wikidata:Q82311374

Synonyms:N-(4-Chloro-2-iodophenyl)-2,2,2-trifluoroacetamide;784183-51-3;SCHEMBL1197587;DTXSID70478156;N-(4-Chloro-2-iodo-phenyl)-2,2,2-trifluoro-acetamide

Suppliers and Price of N-(4-Chloro-2-iodophenyl)-2,2,2-trifluoroacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-Chloro-2-iodophenyl)-2,2,2-trifluoroacetamide

Chemical Property:

XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:348.89782
Heavy Atom Count:15
Complexity:249

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C=C1Cl)I)NC(=O)C(F)(F)F

Technology Process of N-(4-Chloro-2-iodophenyl)-2,2,2-trifluoroacetamide

There total 2 articles about N-(4-Chloro-2-iodophenyl)-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 63069-48-7
p-chloro-o-iodoaniline

: 407-25-0
trifluoroacetic anhydride

: 784183-51-3
N-(4-chloro-2-iodophenyl)-2,2,2-trifluoroacetamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at -7 - 20 ℃;
DOI:10.1002/cmdc.201500383

Reference yield:

: 63069-48-7
p-chloro-o-iodoaniline

: 76-05-1
trifluoroacetic acid

: 784183-51-3
N-(4-chloro-2-iodophenyl)-2,2,2-trifluoroacetamide

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;
DOI:10.1055/s-2005-922790

Reference yield: 80.0%

: 1242029-28-2
N-(prop-2-yn-1-yl)-N-tosylacrylamide

: 784183-51-3
N-(4-chloro-2-iodophenyl)-2,2,2-trifluoroacetamide

: 9-chloro-2-tosyl-1,2,3,4-tetrahydro-5H-[1,4]diazepino[1,2-a]indol-5-one

Guidance literature:: N-(4-chloro-2-iodophenyl)-2,2,2-trifluoroacetamide; With tetrabutylammomium bromide; palladium diacetate; potassium carbonate; triphenylphosphine; In 1,4-dioxane; at 20 ℃; for 0.166667h; Inert atmosphere;

N-(prop-2-yn-1-yl)-N-tosylacrylamide; In 1,4-dioxane; water; at 77 - 80 ℃; for 6h; regioselective reaction; Inert atmosphere;
DOI:10.1002/chem.201406617