N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-4-methylbenzenesulfonamide
• CAS No.: 78439-89-1
• Molecular Formula: C18H19N3O3S
• Molecular Weight: 357.433
• Mol file: 78439-89-1.mol

Synonyms:N-(2,3-dimethyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-4-yl)-4-methylbenzenesulfonamide;1,5-dimethyl-2-phenyl-4-(toluene-4-sulfonylamino)-1,2-dihydro-pyrazol-3-one;4-(p-Toluolsulfonamido)phenazon;N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-4-methyl-benzenesulfonamide;

Chemical Property of N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-4-methylbenzenesulfonamide

Chemical Property:

• Melting Point: 225 - 228 °C (ethanol)
• PSA: 81.48000
• LogP: 3.74740

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-4-methylbenzenesulfonamide

There total 2 articles about N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one (83-07-8) + p-toluenesulfonyl chloride (98-59-9) → N-(2,3-dimethyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-4-yl)-4-methylbenzenesulfonamide (78439-89-1)

Guidance literature:

In tetrahydrofuran; at 60 ℃; for 3h;

Reference yield:

→ N-(2,3-dimethyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-4-yl)-4-methylbenzenesulfonamide (78439-89-1)

Guidance literature:

4-Aminophenazon, p-TsCl;

Reference yield: 61.0%

N-(2,3-dimethyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-4-yl)-4-methylbenzenesulfonamide (78439-89-1) + 1,2-bis(2-tosyloxyethylmercapto)-4,5-dicyanobenzene → N,N’-(((4,5-dicyano-1,2-phenylene)bis(sulfanediyl))bis(ethane-2,1-diyl))bis(N-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl))-4-methylbenzenesulfonamide

Guidance literature:

With sodium carbonate; In acetonitrile; at 95 ℃; for 144h; Inert atmosphere;

DOI:10.1016/j.ica.2017.03.021

upstream raw materials:

4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one

p-toluenesulfonyl chloride