Technology Process of 1H-2-Benzoxacyclotetradecin-1,11(12H)-dione, 3,4,7,8,9,10-hexahydro-14,16-dihydroxy-3-methyl-
There total 8 articles about 1H-2-Benzoxacyclotetradecin-1,11(12H)-dione, 3,4,7,8,9,10-hexahydro-14,16-dihydroxy-3-methyl- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dihydrogen peroxide; sodium hydroxide;
In
tetrahydrofuran;
at 20 ℃;
for 0.5h;
Inert atmosphere;
DOI:10.1021/acs.orglett.6b02575
- Guidance literature:
-
Multi-step reaction with 6 steps
1: mercury(II) oxide; sulfuric acid / acetone / 60 °C / Inert atmosphere
2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere
3: N-Bromosuccinimide; silver nitrate / acetone / 20 h / 0 °C / Inert atmosphere
4: 2,6-di-tert-butyl-4-methyl-phenol / 1,3,5-trimethyl-benzene / 46 h / 150 °C / Inert atmosphere
5: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 4.5 h / 20 - 90 °C / Inert atmosphere
6: sodium hydroxide; dihydrogen peroxide / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere
With
N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; 2,6-di-tert-butyl-4-methyl-phenol; di-isopropyl azodicarboxylate; sulfuric acid; dihydrogen peroxide; potassium acetate; silver nitrate; triphenylphosphine; mercury(II) oxide; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; acetone; 1,3,5-trimethyl-benzene;
2: |Mitsunobu Displacement / 5: |Miyaura Borylation Reaction;
DOI:10.1021/acs.orglett.6b02575
- Guidance literature:
-
Multi-step reaction with 7 steps
1: copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 20 °C / Inert atmosphere
2: mercury(II) oxide; sulfuric acid / acetone / 60 °C / Inert atmosphere
3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere
4: N-Bromosuccinimide; silver nitrate / acetone / 20 h / 0 °C / Inert atmosphere
5: 2,6-di-tert-butyl-4-methyl-phenol / 1,3,5-trimethyl-benzene / 46 h / 150 °C / Inert atmosphere
6: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 4.5 h / 20 - 90 °C / Inert atmosphere
7: sodium hydroxide; dihydrogen peroxide / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; 2,6-di-tert-butyl-4-methyl-phenol; di-isopropyl azodicarboxylate; sulfuric acid; dihydrogen peroxide; potassium acetate; silver nitrate; triethylamine; triphenylphosphine; mercury(II) oxide; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; acetone; 1,3,5-trimethyl-benzene;
1: |Sonogashira Cross-Coupling / 3: |Mitsunobu Displacement / 6: |Miyaura Borylation Reaction;
DOI:10.1021/acs.orglett.6b02575
