Imidazo[1,2-a]pyridine, 2,3-dihydro-2-phenyl-6-(trifluoromethyl)-, (2R)-

Base Information

• Chemical Name: Imidazo[1,2-a]pyridine, 2,3-dihydro-2-phenyl-6-(trifluoromethyl)-, (2R)-
• CAS No.: 785784-11-4
• Molecular Formula: C14H11F3N2
• Molecular Weight: 264.25
• DSSTox Substance ID: DTXSID80459173
• Nikkaji Number: J2.099.267K
• Wikidata: Q82282839

Synonyms:785784-11-4;(R)-2-Phenyl-6-(trifluoromethyl)-2,3-dihydroimidazo[1,2-a]pyridine;Imidazo[1,2-a]pyridine, 2,3-dihydro-2-phenyl-6-(trifluoromethyl)-, (2R)-;(2R)-2,3-dihydro-2-phenyl-6-(trifluoromethyl)-imidazo[1,2-a]pyridine;(2R)-2-phenyl-6-(trifluoromethyl)-2,3-dihydroimidazo[1,2-a]pyridine;CTK2F9789;DTXSID80459173;HSRBEDJTOVKYFL-LBPRGKRZSA-N;CID 11219263;E84635;(2R)-2-phenyl-6-(trifluoromethyl)-2H,3H-imidazo[1,2-a]pyridine

Chemical Property of Imidazo[1,2-a]pyridine, 2,3-dihydro-2-phenyl-6-(trifluoromethyl)-, (2R)-

Chemical Property:

• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 264.08743285
• Heavy Atom Count: 19
• Complexity: 442

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(N=C2N1C=C(C=C2)C(F)(F)F)C3=CC=CC=C3
• Isomeric SMILES: C1[C@H](N=C2N1C=C(C=C2)C(F)(F)F)C3=CC=CC=C3

Technology Process of Imidazo[1,2-a]pyridine, 2,3-dihydro-2-phenyl-6-(trifluoromethyl)-, (2R)-

There total 4 articles about Imidazo[1,2-a]pyridine, 2,3-dihydro-2-phenyl-6-(trifluoromethyl)-, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

→ (R)-5-trifluoromethyl-2-phenyl-2,3-dihydroimidazo[1,2-a]pyridine (785784-11-4)

Guidance literature:

Reference yield: 69.0%

(R)-N-(5-trifluoromethylpyrid-2-yl)-2-hydroxy-1-phenylethylamine (785784-10-3) → (R)-5-trifluoromethyl-2-phenyl-2,3-dihydroimidazo[1,2-a]pyridine (785784-11-4)

Guidance literature:

(R)-N-(5-trifluoromethylpyrid-2-yl)-2-hydroxy-1-phenylethylamine; With thionyl chloride; In chloroform; at 20 - 70 ℃;

With sodium hydroxide; In water; pH=7 - 8;

DOI:10.1016/j.tet.2009.01.058

Reference yield:

((R)-2-Chloro-1-phenyl-ethyl)-(5-trifluoromethyl-pyridin-2-yl)-amine → (R)-5-trifluoromethyl-2-phenyl-2,3-dihydroimidazo[1,2-a]pyridine (785784-11-4)

Guidance literature:

With sodium hydroxide; sodium hydrogencarbonate; In dichloromethane; pH=12;

DOI:10.1021/ja0491477

upstream raw materials:

2-chloro-5-trifluoromethylpyridine

(R)-N-(5-trifluoromethylpyrid-2-yl)-2-hydroxy-1-phenylethylamine

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