2,2,5,5-Tetramethyl-1-(4-methylphenyl)-1-aza-2,5-disilacyclopentane

Base Information

• Chemical Name: 2,2,5,5-Tetramethyl-1-(4-methylphenyl)-1-aza-2,5-disilacyclopentane
• CAS No.: 78605-24-0
• Molecular Formula: C13H23NSi2
• Molecular Weight: 249.503
• DSSTox Substance ID: DTXSID901162929
• Mol file: 78605-24-0.mol

Synonyms:DTXSID901162929;2,2,5,5-Tetramethyl-1-(4-methylphenyl)-1-aza-2,5-disilacyclopentane;78605-24-0

Chemical Property of 2,2,5,5-Tetramethyl-1-(4-methylphenyl)-1-aza-2,5-disilacyclopentane

Chemical Property:

• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 249.13690281
• Heavy Atom Count: 16
• Complexity: 239

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)N2[Si](CC[Si]2(C)C)(C)C

Technology Process of 2,2,5,5-Tetramethyl-1-(4-methylphenyl)-1-aza-2,5-disilacyclopentane

There total 3 articles about 2,2,5,5-Tetramethyl-1-(4-methylphenyl)-1-aza-2,5-disilacyclopentane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1,1'-(1,2-ethanediyl)bis (91166-50-6) + p-toluidine (106-49-0,12221-03-3) → 2,2,5,5-Tetramethyl-1-p-tolyl-[1,2,5]azadisilolidine (78605-24-0)

Guidance literature:

With zinc(II) iodide; for 5h; 1.) 70 deg C, 1h; 2.) 140 deg C, 4 h;

DOI:10.1016/S0040-4039(01)80126-X

Reference yield: 60.0%

1,2-bis-(chlorodimethylsilyl)ethane (13528-93-3) + p-toluidine (106-49-0,12221-03-3) → 2,2,5,5-Tetramethyl-1-p-tolyl-[1,2,5]azadisilolidine (78605-24-0)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -78 - -40 ℃;

DOI:10.1016/S0040-4039(01)90439-3

Reference yield:

1,2-bis-(chlorodimethylsilyl)ethane (13528-93-3) → 2,2,5,5-Tetramethyl-1-p-tolyl-[1,2,5]azadisilolidine (78605-24-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / diethyl ether / 5 h / 0 °C

2: 94 percent / zinc iodide / 5 h / 1.) 70 deg C, 1h; 2.) 140 deg C, 4 h

With zinc(II) iodide; In diethyl ether;

DOI:10.1016/S0040-4039(01)80126-X

upstream raw materials:

1,2-bis-(chlorodimethylsilyl)ethane

p-toluidine

1,1'-(1,2-ethanediyl)bis

Downstream raw materials:

p-toluidine