(4S)-2-Phenyl-4,5-dihydro-1,3-oxazole-4-carbaldehyde

Base Information

Chemical Name:(4S)-2-Phenyl-4,5-dihydro-1,3-oxazole-4-carbaldehyde
CAS No.:78715-84-1
Molecular Formula:C10H9NO2
Molecular Weight:175.187
Hs Code.:
DSSTox Substance ID:DTXSID10575698
Wikidata:Q82465116

Synonyms:78715-84-1;(S)-2-Phenyl-4,5-dihydrooxazole-4-carbaldehyde;(4S)-2-Phenyl-4,5-dihydro-1,3-oxazole-4-carbaldehyde;DTXSID10575698

Suppliers and Price of (4S)-2-Phenyl-4,5-dihydro-1,3-oxazole-4-carbaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of (4S)-2-Phenyl-4,5-dihydro-1,3-oxazole-4-carbaldehyde

Chemical Property:

XLogP3:1.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:175.063328530
Heavy Atom Count:13
Complexity:219

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(N=C(O1)C2=CC=CC=C2)C=O
Isomeric SMILES:C1[C@H](N=C(O1)C2=CC=CC=C2)C=O

Technology Process of (4S)-2-Phenyl-4,5-dihydro-1,3-oxazole-4-carbaldehyde

There total 2 articles about (4S)-2-Phenyl-4,5-dihydro-1,3-oxazole-4-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 78715-83-0
methyl (S)-2-phenyl-4,5-dihydrooxazole-4-carboxylate

: 78715-84-1
4-formyl-2-phenyl-Δ²-oxazoline

Guidance literature:: With diisobutylaluminium hydride;
DOI:10.1016/S0040-4039(00)97608-1

Reference yield:

: 825-60-5
benzimidic acid ethyl ester

: 78715-84-1
4-formyl-2-phenyl-Δ²-oxazoline

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / CH₂Cl₂; H₂O / 16 h

2: DIBAL-H / hexane; toluene / 3 h / -70 °C

With diisobutylaluminium hydride; In hexane; dichloromethane; water; toluene;
DOI:10.1021/jo00335a015

Reference yield:

: 78715-84-1
4-formyl-2-phenyl-Δ²-oxazoline

: Acetic acid (S)-3-oxo-1-((S)-2-phenyl-4,5-dihydro-oxazol-4-yl)-propyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: toluene; diethyl ether; methanol / 2 h / -78 - 20 °C

2: Et₃₂N / CH₂Cl₂ / 20 °C

3: OsO₄; NaIO₄ / tetrahydrofuran; H₂O / 15 h / 20 °C

With sodium periodate; osmium(VIII) oxide; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; toluene;
DOI:10.1021/jo001736h