1-Pyrrolidinecarboxylic acid, 4-azido-2-[[2-oxo-4-[[(phenylmethoxy)carbonyl]amino]-1(2H)-pyrimidinyl ]methyl]-, 1,1-dimethylethyl ester, (2R,4S)-

Base Information

• Chemical Name: 1-Pyrrolidinecarboxylic acid, 4-azido-2-[[2-oxo-4-[[(phenylmethoxy)carbonyl]amino]-1(2H)-pyrimidinyl ]methyl]-, 1,1-dimethylethyl ester, (2R,4S)-
• CAS No.: 787615-25-2
• Molecular Formula: C22H27N7O5
• Molecular Weight: 469.5

Synonyms:

Chemical Property of 1-Pyrrolidinecarboxylic acid, 4-azido-2-[[2-oxo-4-[[(phenylmethoxy)carbonyl]amino]-1(2H)-pyrimidinyl ]methyl]-, 1,1-dimethylethyl ester, (2R,4S)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Pyrrolidinecarboxylic acid, 4-azido-2-[[2-oxo-4-[[(phenylmethoxy)carbonyl]amino]-1(2H)-pyrimidinyl ]methyl]-, 1,1-dimethylethyl ester, (2R,4S)-

There total 2 articles about 1-Pyrrolidinecarboxylic acid, 4-azido-2-[[2-oxo-4-[[(phenylmethoxy)carbonyl]amino]-1(2H)-pyrimidinyl ]methyl]-, 1,1-dimethylethyl ester, (2R,4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

N-benzyloxycarbonyl cytosine (149411-91-6) + (2R,4S)-4-Azido-2-methanesulfonyloxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester (418793-98-3) → 4-azido-2-(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-ylmethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (787615-25-2)

Guidance literature:

With 18-crown-6 ether; potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃;

DOI:10.1039/b407292h

Reference yield:

(2R,4S)-4-azido-2-hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester (418793-94-9) → 4-azido-2-(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-ylmethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (787615-25-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / triethylamine / CH₂Cl₂ / 20 °C

2: 30 percent / K₂CO₃; 18-crown-6 / dimethylformamide / 60 °C

With 18-crown-6 ether; potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/b407292h

Reference yield:

4-azido-2-(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-ylmethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (787615-25-2) → [1-((2R,4S)-4-Azido-pyrrolidin-2-ylmethyl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-carbamic acid benzyl ester

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.166667h;

DOI:10.1039/b407292h

upstream raw materials:

N-benzyloxycarbonyl cytosine

(2R,4S)-4-Azido-2-methanesulfonyloxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester

(2R,4S)-4-azido-2-hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

(4S)-azido-(2R)-(N⁴-benzyloxycarbonylcytosin-1-ylmethyl)pyrrolidin-N-1-acetic acid ethyl ester

[2-(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-ylmethyl)-4-tert-butoxycarbonylamino-pyrrolidin-1-yl]-acetic acid ethyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 787615-25-2 1-Pyrrolidinecarboxylic acid, 4-azido-2-[[2-oxo-4-[[(phenylmethoxy)carbonyl]amino]-1(2H)-pyrimidinyl ]methyl]-, 1,1-dimethylethyl ester, (2R,4S)-

Send

Send

Metric Ton KG G Pound L ML

Send

Send