Azetidine, dihydrochloride

Base Information

• Chemical Name: Azetidine, dihydrochloride
• CAS No.: 78797-58-7
• Molecular Formula: C₃H₇N*ClH
• Molecular Weight: 93.5562
• Mol file: 78797-58-7.mol

Synonyms:

Chemical Property of Azetidine, dihydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Azetidine, dihydrochloride

There total 6 articles about Azetidine, dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

O-tert-butyl azetidine-1-carbothioate → azetidine hydrochloride (78797-58-7,78797-59-8,78797-62-3,36520-39-5,65546-09-0)

Guidance literature:

With hydrogenchloride; In diethyl ether; at 20 ℃; for 1h;

DOI:10.1021/ol503441d

Reference yield: 98.0%

1-[Bis-(4-methoxy-phenyl)-methyl]-azetidine → azetidine hydrochloride (78797-58-7,78797-59-8,78797-62-3,36520-39-5,65546-09-0)

Guidance literature:

With hydrogenchloride; for 14h; Heating;

DOI:10.3987/R-1986-09-2467

Reference yield: 85.0%

malononitrile (109-77-3) → azetidine hydrochloride (78797-58-7,78797-59-8,78797-62-3,36520-39-5,65546-09-0)

Guidance literature:

malononitrile; With C₄₆H₁₇₈O₄₁Si₄₂; titanium(IV)isopropoxide; In toluene; at 100 ℃; for 24h; Inert atmosphere;

With hydrogenchloride; water; In toluene; at 20 ℃; for 4h; chemoselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2013.11.101

upstream raw materials:

N-benzhydryl azetidine

3-azidopropyl diethylboronate

malononitrile

Downstream raw materials:

tert-butyl azetidine-1-carboxylate

phenyl azetidine-1-carboxylate

Azetidine-1-carboxylic acid [4-(4-nitrophenoxy)pyridin-2-yl]amide

3-(azetidin-1-yl)-1-benzhydrylazetidine