n-[(2r)-2-(6-Chloro-5-methoxy-1h-indol-3-yl)propyl]acetamide

Base Information

Chemical Name:n-[(2r)-2-(6-Chloro-5-methoxy-1h-indol-3-yl)propyl]acetamide
CAS No.:118702-11-7
Molecular Formula:C₁₄H₁₇ClN₂O₂
Molecular Weight:280.754
Hs Code.:
UNII:3ZX95B1ZWK
DSSTox Substance ID:DTXSID70922760
Nikkaji Number:J728.853K
Wikipedia:TIK-301
Wikidata:Q6460405
Pharos Ligand ID:JJGVNGB81VXQ
ChEMBL ID:CHEMBL4079759
Mol file:118702-11-7.mol

Synonyms:(R)-N-(2-(6-chloro-5-methoxy-1H-indol-3yl)propyl)acetamide;LY 156735;LY156735

Suppliers and Price of n-[(2r)-2-(6-Chloro-5-methoxy-1h-indol-3-yl)propyl]acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of n-[(2r)-2-(6-Chloro-5-methoxy-1h-indol-3-yl)propyl]acetamide

Chemical Property:

Vapor Pressure:3.76E-11mmHg at 25°C
Boiling Point:525.9°Cat760mmHg
Flash Point:271.9°C
Density:1.237g/cm³
XLogP3:2.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:280.0978555
Heavy Atom Count:19
Complexity:327

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(CNC(=O)C)C1=CNC2=CC(=C(C=C21)OC)Cl
Isomeric SMILES:C[C@@H](CNC(=O)C)C1=CNC2=CC(=C(C=C21)OC)Cl

Technology Process of n-[(2r)-2-(6-Chloro-5-methoxy-1h-indol-3-yl)propyl]acetamide

There total 4 articles about n-[(2r)-2-(6-Chloro-5-methoxy-1h-indol-3-yl)propyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: (R)-2-(6-chloro-5-methoxy-1H-indol-3-yl)propan-1-amine

: 108-24-7
acetic anhydride

: 118702-11-7
LY 156735

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/acs.orglett.8b02335

Reference yield:

: 4920-79-0
2-chloro-4-nitroanisole

: 118702-10-6,118702-11-7
S-(-)-β-methyl-6-chloromelatonin

Guidance literature:: In toluene;

Reference yield:

: tert-butyl (R)-(2-(6-chloro-5-methoxy-1H-indol-3-yl)propyl)carbamate

: 118702-11-7
LY 156735

Guidance literature:: Multi-step reaction with 2 steps

1: (1S)-10-camphorsulfonic acid / isopropyl alcohol / 16 h / 50 °C / Inert atmosphere

2: sodium hydroxide / water; tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With (1S)-10-camphorsulfonic acid; sodium hydroxide; In tetrahydrofuran; water; isopropyl alcohol;
DOI:10.1021/acs.orglett.8b02335