5-Azaspiro[2.5]octane-6,7-dicarboxylic acid, 7-(1,1-dimethylethyl) ester, (6S,7S)-

Base Information

Chemical Name:5-Azaspiro[2.5]octane-6,7-dicarboxylic acid, 7-(1,1-dimethylethyl) ester, (6S,7S)-
CAS No.:791834-47-4
Molecular Formula:C13H21NO4
Molecular Weight:255.314
Hs Code.:

Synonyms:(6S,7S)-7-(tert-butoxycarbonyl)-5-azaspiro[2.5]octane-6-carboxylic acid;5-aza-spiro[2.5]octane-6,7-dicarboxylic acid 7-tert-butyl ester;

Suppliers and Price of 5-Azaspiro[2.5]octane-6,7-dicarboxylic acid, 7-(1,1-dimethylethyl) ester, (6S,7S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Alichem
(6S,7S)-7-(tert-butoxycarbonyl)-5-azaspiro[2.5]octane-6-carboxylicacid
1g
$ 1247.40

Alichem
(6S,7S)-7-(tert-butoxycarbonyl)-5-azaspiro[2.5]octane-6-carboxylicacid
250mg
$ 479.75

Total 5 raw suppliers

Chemical Property of 5-Azaspiro[2.5]octane-6,7-dicarboxylic acid, 7-(1,1-dimethylethyl) ester, (6S,7S)-

Chemical Property:

PSA：75.63000
LogP:1.49980

Purity/Quality:

97% ^*data from raw suppliers

(6S,7S)-7-(tert-butoxycarbonyl)-5-azaspiro[2.5]octane-6-carboxylicacid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-Azaspiro[2.5]octane-6,7-dicarboxylic acid, 7-(1,1-dimethylethyl) ester, (6S,7S)-

There total 8 articles about 5-Azaspiro[2.5]octane-6,7-dicarboxylic acid, 7-(1,1-dimethylethyl) ester, (6S,7S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 791834-46-3
5,6-dibenzyl 7-tert-butyl (6S,7S)-5-azaspiro[2.5]octane-5,6,7-tricarboxylate

: 791834-47-4
(6S,7S)-7-(tert-butoxycarbonyl)-5-azaspiro[2,5]octane-6-carboxylic acid

Guidance literature:: With hydrogen; Pd-BaSO₄; In methanol; at 20 ℃; for 3h;
DOI:10.1021/jm061344o

Reference yield:

: 791834-45-2
1,2-dibenzyl 3-tert-butyl (2S,3S)-5-methylenepiperidine-1,2,3-tricarboxylate

: 791834-47-4
(6S,7S)-7-(tert-butoxycarbonyl)-5-azaspiro[2,5]octane-6-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / palladium(II) acetate / diethyl ether / -20 - 20 °C

2: 98 percent / hydrogen / Pd/BaSO₄ / methanol / 3 h / 20 °C

With hydrogen; Pd-BaSO₄; palladium diacetate; In methanol; diethyl ether;
DOI:10.1055/s-2007-968029

Reference yield:

: 791834-41-8
(S)-2-benzylamino-succinic acid 1-benzyl ester 4-tert-butyl ester

: 791834-47-4
(6S,7S)-7-(tert-butoxycarbonyl)-5-azaspiro[2,5]octane-6-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 70 percent / K₂CO₃; NaI / acetonitrile / 16 h / 81 °C

2: 96 percent / NaI / acetone / 16 h / 20 °C

3: 72 percent / LiHMDS / tetrahydrofuran / 4 h / -78 - -30 °C

4: 93 percent / 28 h / 65 °C

5: 98 percent / palladium(II) acetate / diethyl ether / -20 - 20 °C

6: 98 percent / H₂ / Pd/BaSO₄ / methanol / 3 h / 20 °C

With hydrogen; potassium carbonate; sodium iodide; lithium hexamethyldisilazane; Pd-BaSO₄; palladium diacetate; In tetrahydrofuran; methanol; diethyl ether; acetone; acetonitrile;
DOI:10.1021/jm061344o