Myxochelin A

Base Information

Chemical Name:Myxochelin A
CAS No.:120243-02-9
Molecular Formula:C20H24 N2 O7
Molecular Weight:404.42
Hs Code.:
ChEMBL ID:CHEMBL515742
Metabolomics Workbench ID:70975
Nikkaji Number:J2.378.312F
Wikidata:Q75065886
Mol file:120243-02-9.mol

Synonyms:myxochelin A;N,N'-bis-(2,3-dihydroxybenzoyl)lysinol

Suppliers and Price of Myxochelin A

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
MyxochelinA
25mg
$ 1470.00

Cayman Chemical
Myxochelin A
1mg
$ 315.00

Adipogen Life Sciences
MyxochelinA ≥99%(NMR)
100 μg
$ 90.00

Total 1 raw suppliers

Chemical Property of Myxochelin A

Chemical Property:

Vapor Pressure:6.64E-21mmHg at 25°C
Boiling Point:705.7°Cat760mmHg
Flash Point:380.6°C
PSA：159.35000
Density:1.401g/cm³
LogP:1.98180
XLogP3:2.3
Hydrogen Bond Donor Count:7
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:9
Exact Mass:404.15835111
Heavy Atom Count:29
Complexity:533

Purity/Quality:: MyxochelinA ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C(=C1)O)O)C(=O)NCCCCC(CO)NC(=O)C2=C(C(=CC=C2)O)O
Isomeric SMILES:C1=CC(=C(C(=C1)O)O)C(=O)NCCCC[C@@H](CO)NC(=O)C2=C(C(=CC=C2)O)O
Description Myxochelin A is a microbial metabolite that has been found in A. disciformis and has diverse biological activities. It is active against Gram-positive bacteria, including B. cereus, S. aureus, and M. luteus, but not Gram-negative bacteria or fungi in an agar diffusion assay when used at a concentration of 80 μg/disc. Myxochelin A inhibits 5-lipoxygenase (5-LO) activity with an IC50 value of 1.9 μM for the recombinant human enzyme. It is cytotoxic to 26-L5 colon cancer cells when used at a concentration of 3 μg/ml.
Uses Myxochelin A is a potent inhibitor of human 5-lipoxygenase (5-LO). Studies show that Myxochelin A is a natural product that may possess potent antitumor activity at non-cytotoxic concentrations.

Technology Process of Myxochelin A

There total 4 articles about Myxochelin A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: (S)-N,N'-(6-hydroxyhexane-1,5-diyl)bis(2,3-dimethoxybenzamide)

: 120243-02-9
myxochelin A

Guidance literature:: With boron tribromide; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.tetlet.2016.02.047

Reference yield:

: 56-87-1,3506-25-0
L-lysine

: 303-38-8
2,3-Dihydroxybenzoic acid

: C₂₀H₂₂N₂O₇

: 120243-02-9
myxochelin A

: myxochelin B

Guidance literature:: With MxcE; MxcF; MxcG; MxcL; glutamate; at 37 ℃; pH=7.6;
DOI:10.1021/ja8025278

Reference yield:

: 3844-53-9,5721-12-0
L-lysine ethyl ester dihydrochloride

: 120243-02-9
myxochelin A

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

2: lithium borohydride / tetrahydrofuran / 4 - 20 °C / Inert atmosphere

3: boron tribromide / dichloromethane / 16 h / 20 °C / Inert atmosphere

With lithium borohydride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; boron tribromide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2016.02.047