Technology Process of 2-Propenoic acid,
(2S)-2-[(Z)-[(2E)-1-cyano-2-butenylidene]amino]-2-phenylethyl ester
There total 3 articles about 2-Propenoic acid,
(2S)-2-[(Z)-[(2E)-1-cyano-2-butenylidene]amino]-2-phenylethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(S)-acrylic acid 2-but-2-enoylamino-2-phenylethyl ester;
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at -60 ℃;
for 1h;
With
trifluoromethylsulfonic anhydride;
In
dichloromethane;
at -60 ℃;
for 2h;
lithium cyanide;
With
(1,4,7,10-tetraoxacyclododecane);
In
tetrahydrofuran; dichloromethane;
at -73 - -20 ℃;
for 2h;
Further stages.;
DOI:10.1016/j.tet.2004.08.089
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 97 percent / aq. na2CO3 / CH2Cl2
2.1: 93 percent / aq. KOH; TBAI / CH2Cl2 / 0.33 h / 0 °C
3.1: iPr2NEt / CH2Cl2 / 1 h / -60 °C
3.2: Tf2O / CH2Cl2 / 2 h / -60 °C
3.3: 21 percent / 12-crown-4 / CH2Cl2; tetrahydrofuran / 2 h / -73 - -20 °C
With
potassium hydroxide; tetra-(n-butyl)ammonium iodide; sodium carbonate; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
DOI:10.1016/j.tet.2004.08.089
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 93 percent / aq. KOH; TBAI / CH2Cl2 / 0.33 h / 0 °C
2.1: iPr2NEt / CH2Cl2 / 1 h / -60 °C
2.2: Tf2O / CH2Cl2 / 2 h / -60 °C
2.3: 21 percent / 12-crown-4 / CH2Cl2; tetrahydrofuran / 2 h / -73 - -20 °C
With
potassium hydroxide; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
DOI:10.1016/j.tet.2004.08.089
