(Z)-1-(2',6'-Dichlorophenyl)-3-(beta,gamma-dihydroxypropyl)aminomethylene-2-indolinone

Base Information

• Chemical Name: (Z)-1-(2',6'-Dichlorophenyl)-3-(beta,gamma-dihydroxypropyl)aminomethylene-2-indolinone
• CAS No.: 172371-96-9
• Molecular Formula: C₁₈H₁₆Cl₂N₂O₃
• Molecular Weight: 379.243
• Hs Code.: 2933790090
• Mol file: 172371-96-9.mol

Synonyms:172371-96-9;(Z)-1-(2',6'-Dichlorophenyl)-3-(beta,gamma-dihydroxypropyl)aminomethylene-2-indolinone;3-[[1-(2,6-dichlorophenyl)-2-hydroxyindol-3-yl]methylideneamino]propane-1,2-diol;2H-Indol-2-one, 1,3-dihydro-1-(2,6-dichlorophenyl)-3-(((2,3-dihydroxypropyl)amino)methylene)-, (Z)-;2H-Indol-2-one,1-(2,6-dichlorophenyl)-3-[[(2,3-dihydroxypropyl)amino]methylene]-1,3-dihydro-,(Z)- (9CI);VOIONHKFHXSKPD-LCYFTJDESA-N;LS-83778

Chemical Property of (Z)-1-(2',6'-Dichlorophenyl)-3-(beta,gamma-dihydroxypropyl)aminomethylene-2-indolinone

Chemical Property:

• Vapor Pressure: 4.93E-16mmHg at 25°C
• Refractive Index: 1.723
• Boiling Point: 616 °C at 760 mmHg
• Flash Point: 326.4 °C
• PSA: 72.80000
• Density: 1.525g/cm³
• LogP: 3.41130
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 378.0537978
• Heavy Atom Count: 25
• Complexity: 458

Purity/Quality:

99% ^*data from raw suppliers

(Z)-1-(2',6'-Dichlorophenyl)-3-(beta,gamma-dihydroxypropyl)aminomethylene-2-indolinone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(=C(N2C3=C(C=CC=C3Cl)Cl)O)C=NCC(CO)O

Technology Process of (Z)-1-(2',6'-Dichlorophenyl)-3-(beta,gamma-dihydroxypropyl)aminomethylene-2-indolinone

There total 4 articles about (Z)-1-(2',6'-Dichlorophenyl)-3-(beta,gamma-dihydroxypropyl)aminomethylene-2-indolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2,6-dichlorophenyl)indolin-2-one (15362-40-0) → (Z)-1-(2',6'-dichlorophenyl)-3-(β,γ-dihydroxypropyl)aminomethylene-2-indolinone (172371-96-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / propan-2-ol / 22 h / 20 °C

2: propan-2-ol / 6 h

In isopropyl alcohol;

DOI:10.1007/BF02226519

Reference yield:

1-(2,6-dichlorophenyl)indolin-2-one (15362-40-0) → (E)-1-(2',6'-dichlorophenyl)-3-(β,γ-dihydroxypropyl)aminomethylene-2-indolinone (172371-96-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / propan-2-ol / 22 h / 20 °C

2: propan-2-ol / 6 h

In isopropyl alcohol;

DOI:10.1007/BF02226519

Reference yield:

3-Amino-1,2-propanediol (616-30-8,13552-31-3,98923-21-8) + 1-(2',6'-dichlorophenyl)-3-dimethylaminomethylene-2-indolinone (175983-50-3,172371-89-0) → (Z)-1-(2',6'-dichlorophenyl)-3-(β,γ-dihydroxypropyl)aminomethylene-2-indolinone (172371-96-9) + (E)-1-(2',6'-dichlorophenyl)-3-(β,γ-dihydroxypropyl)aminomethylene-2-indolinone (172371-96-9)

Guidance literature:

In isopropyl alcohol; for 6h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1007/BF02226519

upstream raw materials:

3-Amino-1,2-propanediol

1-(2',6'-dichlorophenyl)-3-dimethylaminomethylene-2-indolinone

1-(2,6-dichlorophenyl)indolin-2-one

Refernces