Technology Process of 2-Butynoic acid,
4-[(2R,6R)-6-[2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]ethyl]tetrahydro-4-
methylene-2H-pyran-2-yl]-, methyl ester
There total 5 articles about 2-Butynoic acid,
4-[(2R,6R)-6-[2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]ethyl]tetrahydro-4-
methylene-2H-pyran-2-yl]-, methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
{2-[(2R,6R)-6-(3-Bromo-prop-2-ynyl)-4-methylene-tetrahydro-pyran-2-yl]-ethoxy}-tert-butyl-diphenyl-silane;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 0.5h;
methyl chloroformate;
With
N,N,N,N,N,N-hexamethylphosphoric triamide;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 0.5h;
DOI:10.1039/b407240e
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: PPh3 / CH2Cl2 / 0.17 h / -10 °C
1.2: 98 percent / CH2Cl2 / 0.5 h / -10 °C
2.1: 99 percent / NaHMDS / tetrahydrofuran / 1 h / -98 °C
3.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C
3.2: 86 percent / HMPA / tetrahydrofuran; hexane / 0.5 h / -78 °C
With
n-butyllithium; sodium hexamethyldisilazane; triphenylphosphine;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1039/b407240e
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 8.38 g / aq. NMO; OsO4 / tetrahydrofuran; 2-methyl-propan-2-ol / 24 h / 20 °C
2.1: PhLi / tetrahydrofuran; cyclohexane; diethyl ether / 2 h / 0 °C
2.2: 7.61 g / tetrahydrofuran; cyclohexane; diethyl ether / 3 h / -40 - -20 °C
3.1: 5.73 g / Na2CO3; Pb(OAc)4 / CH2Cl2 / 1.5 h / 0 - 20 °C
4.1: PPh3 / CH2Cl2 / 0.17 h / -10 °C
4.2: 98 percent / CH2Cl2 / 0.5 h / -10 °C
5.1: 99 percent / NaHMDS / tetrahydrofuran / 1 h / -98 °C
6.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C
6.2: 86 percent / HMPA / tetrahydrofuran; hexane / 0.5 h / -78 °C
With
lead(IV) acetate; osmium(VIII) oxide; n-butyllithium; N-methyl-2-indolinone; sodium hexamethyldisilazane; sodium carbonate; phenyllithium; triphenylphosphine;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; cyclohexane; tert-butyl alcohol;
2.2: Wittig methylenation;
DOI:10.1039/b407240e
![{2-[(2R,6R)-6-(3-Bromo-prop-2-ynyl)-4-methylene-tetrahydro-pyran-2-yl]-ethoxy}-tert-butyl-diphenyl-silane](/Databaselist/images/loading.webp)
