L-Alanine, N-[[4-(13,13-dimethyl-11-oxo-4,7,12-trioxa-10-azatetradec-1-yl)phenyl] sulfonyl]-3-[[4-[2-[6-(methylamino)-2-pyridinyl]ethyl]benzoyl]amino]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:L-Alanine, N-[[4-(13,13-dimethyl-11-oxo-4,7,12-trioxa-10-azatetradec-1-yl)phenyl] sulfonyl]-3-[[4-[2-[6-(methylamino)-2-pyridinyl]ethyl]benzoyl]amino]-, 1,1-dimethylethyl ester
CAS No.:801239-54-3
Molecular Formula:C40H57N5O9S
Molecular Weight:783.987
Hs Code.:

L-Alanine,
N-[[4-(13,13-dimethyl-11-oxo-4,7,12-trioxa-10-azatetradec-1-yl)phenyl]
sulfonyl]-3-[[4-[2-[6-(methylamino)-2-pyridinyl]ethyl]benzoyl]amino]-,
1,1-dimethylethyl ester

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of L-Alanine, N-[[4-(13,13-dimethyl-11-oxo-4,7,12-trioxa-10-azatetradec-1-yl)phenyl] sulfonyl]-3-[[4-[2-[6-(methylamino)-2-pyridinyl]ethyl]benzoyl]amino]-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of L-Alanine, N-[[4-(13,13-dimethyl-11-oxo-4,7,12-trioxa-10-azatetradec-1-yl)phenyl] sulfonyl]-3-[[4-[2-[6-(methylamino)-2-pyridinyl]ethyl]benzoyl]amino]-, 1,1-dimethylethyl ester

There total 9 articles about L-Alanine, N-[[4-(13,13-dimethyl-11-oxo-4,7,12-trioxa-10-azatetradec-1-yl)phenyl] sulfonyl]-3-[[4-[2-[6-(methylamino)-2-pyridinyl]ethyl]benzoyl]amino]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 801240-19-7
4-[2-(6-methylamino-pyridin-2-yl)-ethyl]-benzoic acid

: 801240-24-4
3-amino-2-(4-{3-[2-(2-tert-butoxycarbonylamino-ethoxy)-ethoxy]-propyl}-benzenesulfonylamino)-propionic acid tert-butyl ester

: 801239-54-3
2-(4-{3-[2-(2-tert-butoxycarbonylamino-ethoxy)-ethoxy]-propyl}-benzenesulfonylamino)-3-{4-[2-(6-methylamino-pyridin-2-yl)-ethyl]-benzoylamino}-propionic acid tert-butyl ester

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1021/jm049666k

Reference yield:

: 10602-03-6
ethyl 4-ethynylbenzoate

: 801239-54-3
2-(4-{3-[2-(2-tert-butoxycarbonylamino-ethoxy)-ethoxy]-propyl}-benzenesulfonylamino)-3-{4-[2-(6-methylamino-pyridin-2-yl)-ethyl]-benzoylamino}-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 74 percent / Pd(PPh₃)2Cl₂; CuI; Et₃N / various solvent(s) / 16 h / 90 °C

2: H₂ / Pd/C / ethanol / 16 h

3: 260 mg / aq. NaOH / methanol; tetrahydrofuran / 16 h / 20 °C

4: 79 percent / EDC; HOBT; NMM / dimethylformamide / 16 h / 20 °C

With 4-methyl-morpholine; bis-triphenylphosphine-palladium(II) chloride; sodium hydroxide; copper(l) iodide; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; 1: Sonogashira coupling;
DOI:10.1021/jm049666k

Reference yield:

: 98-58-8
4-bromobenzenesulfonyl chloride

: 801239-54-3
2-(4-{3-[2-(2-tert-butoxycarbonylamino-ethoxy)-ethoxy]-propyl}-benzenesulfonylamino)-3-{4-[2-(6-methylamino-pyridin-2-yl)-ethyl]-benzoylamino}-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: Et₃N / tetrahydrofuran; H₂O / 20 °C

2.1: Br₂; aq. NaOH / 0 - 85 °C

2.2: H₂SO₄

2.3: aq. NaHCO₃ / diethyl ether

3.1: Pd(PPh₃)2Cl₂; CuI; Et₃N / various solvent(s)

4.1: H₂ / Pd/C / ethanol

5.1: 79 percent / EDC; HOBT; NMM / dimethylformamide / 16 h / 20 °C

With 4-methyl-morpholine; bis-triphenylphosphine-palladium(II) chloride; sodium hydroxide; copper(l) iodide; hydrogen; bromine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm049666k