Technology Process of 4-Hexen-3-one, 6,6,6-trifluoro-1-phenyl-, (4E)-
There total 5 articles about 4-Hexen-3-one, 6,6,6-trifluoro-1-phenyl-, (4E)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
P(p-CH3OC6H4)3; 1,1'-azodicarbonyl-dipiperidine; phenol;
In
tetrahydrofuran; toluene;
at 66 ℃;
for 3h;
optical yield given as %de;
diastereoselective reaction;
Inert atmosphere;
DOI:10.1021/jo102503s
- Guidance literature:
-
With
dipyridinium dichromate; acetic anhydride;
In
dichloromethane;
for 1h;
Heating;
DOI:10.1021/ol048229x
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 99 percent / LDA / tetrahydrofuran / 0.5 h / -78 °C
2: 92 percent / Red-Al / toluene / 3 h / -78 °C
3: 80 percent / pyridinium dichromate; Ac2O / CH2Cl2 / 1 h / Heating
With
dipyridinium dichromate; acetic anhydride; sodium bis(2-methoxyethoxy)aluminium dihydride; lithium diisopropyl amide;
In
tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/ol048229x
