trans-1,2-Cyclobutanedicarboxylic acid dichloride

Base Information

Chemical Name:trans-1,2-Cyclobutanedicarboxylic acid dichloride
CAS No.:3668-43-7
Molecular Formula:C₆H₆Cl₂O₂
Molecular Weight:181.018
Hs Code.:
Nikkaji Number:J2.982.724I

Synonyms:SCHEMBL7271372;UKHMRFDNOROHOX-QWWZWVQMSA-N;trans-1,2-cyclobutanedicarbonylchloride;trans-Cyclobutane-1,2-dicarbonyl dichloride;trans-1,2-cyclobutanedicarboxylic acid dichloride

Suppliers and Price of trans-1,2-Cyclobutanedicarboxylic acid dichloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of trans-1,2-Cyclobutanedicarboxylic acid dichloride

Chemical Property:

Vapor Pressure:0.128mmHg at 25°C
Boiling Point:218.1°Cat760mmHg
Flash Point:93.3°C
Density:1.468g/cm³
XLogP3:1.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:179.9744848
Heavy Atom Count:10
Complexity:159

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(C1C(=O)Cl)C(=O)Cl
Isomeric SMILES:C1C[C@H]([C@@H]1C(=O)Cl)C(=O)Cl

Technology Process of trans-1,2-Cyclobutanedicarboxylic acid dichloride

There total 8 articles about trans-1,2-Cyclobutanedicarboxylic acid dichloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1124-13-6,1461-94-5,3396-14-3,17224-72-5,58616-94-7,58616-97-0
(+/-)-(1S,2S)-cyclobutane-1,2-dicarboxylic acid

: 3668-43-7,45775-91-5,45775-94-8,89380-29-0
trans-cyclobutane-1,2-dicarbonyl dichloride

Guidance literature:: With thionyl chloride; In benzene; at 70 ℃; for 24h;
DOI:10.1016/S0957-4166(02)00757-7

Reference yield:

: 124-04-9
Adipic acid

: 3668-43-7,45775-91-5,45775-94-8,89380-29-0
trans-cyclobutane-1,2-dicarbonyl dichloride

Guidance literature:: Multi-step reaction with 7 steps

1: SOCl₂ / 7 h / Heating

2: bromine

3: 71 percent / methanol / 56 h / 75 °C

4: aq. HCl / 12 h / Heating

5: 180 °C / water pump

6: 96 percent / SOCl₂ / benzene / 24 h / 70 °C

With hydrogenchloride; thionyl chloride; bromine; In methanol; benzene;
DOI:10.1016/S0957-4166(02)00757-7

Reference yield:

: 868-72-4,53490-47-4,124819-17-6
dimethyl 2,5-dibromohexanedioate

: 3668-43-7,45775-91-5,45775-94-8,89380-29-0
trans-cyclobutane-1,2-dicarbonyl dichloride

Guidance literature:: Multi-step reaction with 4 steps

1: 71 percent / methanol / 56 h / 75 °C

2: aq. HCl / 12 h / Heating

3: 180 °C / water pump

4: 96 percent / SOCl₂ / benzene / 24 h / 70 °C

With hydrogenchloride; thionyl chloride; In methanol; benzene;
DOI:10.1016/S0957-4166(02)00757-7