Tyrosine, a-(2,2-dimethoxyethyl)-O-(1,1-dimethylethyl)-, methyl ester

Base Information

• Chemical Name: Tyrosine, a-(2,2-dimethoxyethyl)-O-(1,1-dimethylethyl)-, methyl ester
• CAS No.: 802912-28-3
• Molecular Formula: C18H29NO5
• Molecular Weight: 339.432
• Mol file: 802912-28-3.mol

Synonyms:

Chemical Property of Tyrosine, a-(2,2-dimethoxyethyl)-O-(1,1-dimethylethyl)-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Tyrosine, a-(2,2-dimethoxyethyl)-O-(1,1-dimethylethyl)-, methyl ester

There total 2 articles about Tyrosine, a-(2,2-dimethoxyethyl)-O-(1,1-dimethylethyl)-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,S)-2-(benzyloxycarbonylamino)-2-(4-tert-butoxyphenylmethyl)-4,4-dimethoxybutanoic acid methyl ester (802912-27-2) → (2R,S)-2-amino-2-(4-tert-butoxyphenylmethyl)-4,4-dimethoxybutanoic acid methyl ester (802912-28-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 65 ℃; for 0.666667h;

DOI:10.1021/jm049651m

Reference yield:

(4R,S)-3-(benzyloxycarbonyl)-4-(4-tert-butoxyphenylmethyl)-4-(2,2-dimethoxyethyl)-1,3-oxazolidin-5-one (802912-26-1) → (2R,S)-2-amino-2-(4-tert-butoxyphenylmethyl)-4,4-dimethoxybutanoic acid methyl ester (802912-28-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / NaOMe / methanol / 2.5 h / Heating

2: H₂ / Pd/C / ethanol / 0.67 h / 65 °C

With hydrogen; sodium methylate; palladium on activated charcoal; In methanol; ethanol;

DOI:10.1021/jm049651m

Reference yield:

(2R,S)-2-amino-2-(4-tert-butoxyphenylmethyl)-4,4-dimethoxybutanoic acid methyl ester (802912-28-3) → 2-amino-2-(4-tert-butoxy-benzyl)-4,4-dimethoxy-butyric acid

Guidance literature:

With potassium hydroxide; In methanol; for 3h; Heating;

DOI:10.1021/jm049651m

upstream raw materials:

(2R,S)-2-(benzyloxycarbonylamino)-2-(4-tert-butoxyphenylmethyl)-4,4-dimethoxybutanoic acid methyl ester

(4R,S)-3-(benzyloxycarbonyl)-4-(4-tert-butoxyphenylmethyl)-4-(2,2-dimethoxyethyl)-1,3-oxazolidin-5-one

Downstream raw materials:

(2R,S)-2-(4-tert-butoxyphenylmethyl)-2-[(9-fluorenylmethoxycarbonyl)amino]-4,4-dimethoxybutanoic acid

Refernces