Cinacalcet IMpurity 7

Base Information

Chemical Name:Cinacalcet IMpurity 7
CAS No.:802918-47-4
Molecular Formula:C22H24F3N
Molecular Weight:359.434
Hs Code.:

Synonyms:[1-(5,6-Dihydro-naphthalen-1-yl)-ethyl]-[3-(3-trifluoromethyl-phenyl)-propyl]-amine;

Suppliers and Price of Cinacalcet IMpurity 7

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Cinacalcet IMpurity 7

Chemical Property:

PSA：12.03000
LogP:6.33910

Purity/Quality:: > 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Cinacalcet IMpurity 7

There total 11 articles about Cinacalcet IMpurity 7 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 104774-87-0
3‐[3‐(trifluoromethyl)phenyl]propan‐1‐amine

: 802918-49-6
1-(5,6-dihydro-naphthalen-1-yl)-ethanone

: 802918-47-4,802918-36-1
[1-(5,6-dihydronaphthalen-1-yl)ethyl]-[3-(3-trifluoromethylphenyl)propyl]amine

Guidance literature:: 3‐[3‐(trifluoromethyl)phenyl]propan‐1‐amine; 1-(5,6-dihydro-naphthalen-1-yl)-ethanone; With titanium(IV) isopropylate; at 20 ℃; Neat (no solvent);

With sodium tetrahydroborate; In methanol; at 20 ℃; for 1h;

Reference yield:

: 60689-14-7,64379-91-5
trans-3-(trifluoromethyl)cinnamoyl chloride

: 802918-47-4,802918-36-1
[1-(5,6-dihydronaphthalen-1-yl)ethyl]-[3-(3-trifluoromethylphenyl)propyl]amine

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / NH₄OH / dioxane / 0 °C

2: 89 percent / H₂ / Pd/C / methanol / 16 h / 20 °C

3: 65 percent / LAH / tetrahydrofuran / 4 h / Heating

4: Ti(OiPr)4

5: NaBH₄ / methanol

With titanium(IV) isopropylate; ammonium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol;
DOI:10.1016/j.tetlet.2004.09.063

Reference yield:

: 64380-24-1
(E)-3-(3-(trifluoromethyl)phenyl)acrylamide

: 802918-47-4,802918-36-1
[1-(5,6-dihydronaphthalen-1-yl)ethyl]-[3-(3-trifluoromethylphenyl)propyl]amine

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / H₂ / Pd/C / methanol / 16 h / 20 °C

2: 65 percent / LAH / tetrahydrofuran / 4 h / Heating

3: Ti(OiPr)4

4: NaBH₄ / methanol

With titanium(IV) isopropylate; sodium tetrahydroborate; lithium aluminium tetrahydride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1016/j.tetlet.2004.09.063