2-(Thiophen-2-yl)quinoline-4-carbohydrazide

Base Information

• Chemical Name: 2-(Thiophen-2-yl)quinoline-4-carbohydrazide
• CAS No.: 39072-28-1
• Molecular Formula: C14H11N3OS
• Molecular Weight: 269.3216
• Hs Code.: 2934999090
• European Community (EC) Number: 673-255-4
• ChEMBL ID: CHEMBL1501041
• DSSTox Substance ID: DTXSID30408338
• Wikidata: Q82213799
• Mol file: 39072-28-1.mol

Synonyms:39072-28-1;2-(thiophen-2-yl)quinoline-4-carbohydrazide;2-thien-2-ylquinoline-4-carbohydrazide;2-Thiophen-2-yl-quinoline-4-carboxylic acid hydrazide;2-thiophen-2-ylquinoline-4-carbohydrazide;2-thienylcinchoninic hydrazide;MLS001004792;2-thiophen-2-ylquinoline-4-carboxylic acid hydrazide;CHEMBL1501041;SCHEMBL23722824;DTXSID30408338;HMS2775K10;MFCD01812612;AKOS000122513;SB86090;2-(2-thienyl)quinoline-4-carbohydrazide;SMR000348312;VS-14318;FT-0639521;EN300-03761;A924547;2-Thiophen-2-yl-quinoline-4-carboxylicacidhydrazide;2-thiophen-2-yl-quinoline-4-carboxylic acidhydrazide;Z56790582

Chemical Property of 2-(Thiophen-2-yl)quinoline-4-carbohydrazide

Chemical Property:

• Melting Point: 237-237.5 °C(Solv: ethanol (64-17-5))
• Boiling Point: °Cat760mmHg
• PKA: 11.40±0.30(Predicted)
• Flash Point: °C
• PSA: 96.25000
• Density: 1.352g/cm³
• LogP: 3.65800
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 269.06228316
• Heavy Atom Count: 19
• Complexity: 339

Purity/Quality:

97% ^*data from raw suppliers

2-Thien-2-ylquinoline-4-carbohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(=CC(=N2)C3=CC=CS3)C(=O)NN

Technology Process of 2-(Thiophen-2-yl)quinoline-4-carbohydrazide

There total 6 articles about 2-(Thiophen-2-yl)quinoline-4-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

C15H11NO2S (350997-63-6) → 2-(thiophen-2-yl)quinoline-4-carbohydrazide (39072-28-1)

Guidance literature:

With hydrazine hydrochloride; sodium hydroxide; In ethanol; for 20h; Reflux;

DOI:10.1016/j.jfluchem.2016.08.012

Reference yield: 77.0%

→ 2-(thiophen-2-yl)quinoline-4-carbohydrazide (39072-28-1)

Guidance literature:

With sodium hydroxide; In water; for 0.5h; Inert atmosphere;

In tetrahydrofuran; water; at 20 ℃; Inert atmosphere;

With hydrogenchloride;

Reference yield:

2-(thiophen-2-yl)quinoline-4-carboxylic acid (31792-47-9) → 2-(thiophen-2-yl)quinoline-4-carbohydrazide (39072-28-1)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂SO₄

2: N₂H₄*H₂O

With sulfuric acid; hydrazine hydrate;

DOI:10.1007/BF00771295

upstream raw materials:

2-thiophen-2-yl-quinoline-4-carboxylic acid ethyl ester

2-(thiophen-2-yl)quinoline-4-carboxylic acid

indole-2,3-dione

2-Acetylthiophene

Downstream raw materials:

2-thiophen-2-yl-quinoline-4-carboxylic acid (3-nitro-benzylidene)-hydrazide

2-thiophen-2-yl-quinoline-4-carboxylic acid (4-nitro-benzylidene)-hydrazide

2-thiophen-2-yl-quinoline-4-carboxylic acid benzylidenehydrazide

2-thiophen-2-yl-quinoline-4-carboxylic acid (4-methoxy-benzylidene)-hydrazide