N-(guanin-8-yl)-N-acetyl-2-aminofluorene

Base Information

Chemical Name:N-(guanin-8-yl)-N-acetyl-2-aminofluorene
CAS No.:14490-85-8
Molecular Formula:C₂₀H₁₆N₆O₂
Molecular Weight:372.386
Hs Code.:
Mol file:14490-85-8.mol

Synonyms:Acetamide,N-(2-amino-1,6-dihydro-6-oxopurin-8-yl)-N-fluoren-2-yl- (8CI); Acetamide, N-(2-amino-6,7-dihydro-6-oxo-1H-purin-8-yl)-N-9H-fluoren-2-yl-(9CI); 8-(N-2-Fluorenylacetoamido)guanine

Suppliers and Price of N-(guanin-8-yl)-N-acetyl-2-aminofluorene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of N-(guanin-8-yl)-N-acetyl-2-aminofluorene

Chemical Property:

Vapor Pressure:3.89E-20mmHg at 25°C
Boiling Point:712.3°Cat760mmHg
PKA:9.30±0.20(Predicted)
Flash Point:384.6°C
PSA：362.30000
Density:1.6g/cm³
LogP:4.21290

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N-(guanin-8-yl)-N-acetyl-2-aminofluorene

There total 15 articles about N-(guanin-8-yl)-N-acetyl-2-aminofluorene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 37819-60-6
fluorene

: 14490-85-8
8->guanine

Guidance literature:: With dichloro-acetic acid; In methanol; dichloromethane; Ambient temperature;
DOI:10.1021/jo00082a011

Reference yield:

: 118-00-3
G

: 14490-85-8
8->guanine

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / p-TsOH / acetone / 5 h / 25 °C

2: 60 percent / DMAP / dimethylformamide / 4 h / 90 °C

3: 1) N-methylmorpholine, ClCOOiBu / 1) DMF, 15 min, -20 deg C, 2) -20 deg C, 5 min, then rt, 15 min

4: 30 percent / acetone; H₂O / 8 h / 40 °C / pH 9.2 (carbonate buffer)

5: aq. HCl / methanol / 0.25 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; dmap; isobutyl chloroformate; toluene-4-sulfonic acid; In methanol; water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4020(01)86525-X

Reference yield:

: N-[2-Amino-6-oxo-9-((2R,4S,5R)-4-trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-2-yl)-6,9-dihydro-1H-purin-8-yl]-N-(9H-fluoren-2-yl)-acetamide

: 14490-85-8
8->guanine

Guidance literature:: Multi-step reaction with 4 steps

2: 3percent AcOH / CH₂Cl₂

3: dichloroacetic acid / CH₂Cl₂ / Ambient temperature

4: triethylamine / CH₂Cl₂; methanol / 2 h / Ambient temperature

With dichloro-acetic acid; acetic acid; triethylamine; In methanol; dichloromethane;
DOI:10.1021/jo00082a011